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Nuclear Cloning and Direct Reprogramming: The Long and the Short Path to Stockholm

Author(s)
Jaenisch, Rudolf
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.

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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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Abstract
This year’s Nobel Prize in Physiology or Medicine was awarded to John Gurdon and Shinya Yamanaka for solving key problems of biology. Their work provided fundamental insights into how an egg gives rise to a complex organism consisting of many different cell types and has transformed our understanding of nuclear reprogramming, of embryonic development, and of cellular differentiation. These are issues that have a long history and the reader is referred to a comprehensive review by Graf (2011) on cellular plasticity and a summary of current issues of the reprogramming field by Yamanaka (2012). Here I will give a personal view on how the discoveries of Gurdon and Yamanaka have shaped our understanding of basic mechanisms of development and how stem cells will revolutionize the way we investigate human disease and establish novel treatment strategies.
Date issued
2012-12
URI
http://hdl.handle.net/1721.1/84640
Department
Massachusetts Institute of Technology. Department of Biology
Journal
Cell Stem Cell
Publisher
Elsevier
Citation
Jaenisch, Rudolf. “Nuclear Cloning and Direct Reprogramming: The Long and the Short Path to Stockholm.” Cell Stem Cell 11, no. 6 (December 2012): 744-747. Copyright © 2012 Elsevier Inc.
Version: Final published version
ISSN
19345909

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