NF-κB Fans the Flames of Lung Carcinogenesis
Author(s)Jacks, Tyler E.; Wong, Kwok-Kin; Dranoff, Glenn
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This perspective on Deng et al. (beginning on p. 424 in this issue of the journal) examines the link between NF-κB and lung tumorigenesis. Experiments in genetically engineered mouse models of lung cancers are elucidating protumorigenic roles of NF-κB activation in lung cancer pathogenesis. Our growing understanding of the tumor-promoting NF-κB downstream effector pathways could lead to the development of novel approaches for lung cancer therapy and chemoprevention.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT
Cancer Prevention Research
American Association for Cancer Research
Wong, K. K., T. Jacks, and G. Dranoff. “NF- B Fans the Flames of Lung Carcinogenesis.” Cancer Prevention Research 3, no. 4 (April 4, 2010): 403-405.
Author's final manuscript