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MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte–erythroid progenitor lineage commitment

Author(s)
Zhang, L.; Sankaran, Vijay G.; Lodish, Harvey F
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Abstract
MicroRNAs (miRNAs) are a class of small regulatory noncoding RNAs that modulate the expression of their target genes through either mRNA degradation or inhibition of protein translation. In recent years, miRNAs have been shown to be critical regulators of hematopoiesis and have important roles in the differentiation of specific lineages. Here, we summarize our current understanding of miRNAs involved in hematopoiesis with a focus on the role of miRNAs in regulating erythroid and megakaryocytic differentiation and megakaryocyte–erythroid progenitor lineage commitment.
Date issued
2012-05
URI
http://hdl.handle.net/1721.1/84702
Department
Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Journal
Leukemia
Publisher
Nature Publishing Group
Citation
Zhang, L, V G Sankaran, and H F Lodish. “MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte–erythroid progenitor lineage commitment.” Leukemia 26, no. 11 (May 23, 2012): 2310-2316.
Version: Author's final manuscript
ISSN
0887-6924
1476-5551

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