Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
Author(s)
Narayan, Kavitha; Sylvia, Katelyn E.; Malhotra, Nidhi; Yin, Catherine C.; Martens, Gregory; Vallerskog, Therese; Kornfeld, Hardy; Xiong, Na; Cohen, Nadia R.; Brenner, Michael B.; Berg, Leslie J.; Kang, Joonsoo; Immunological Genome Project Consortium; Regev, Aviv; ... Show more Show less
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Innate γδ T cells function in the early phase of immune responses. Although innate γδ T cells have often been studied as one homogenous population, they can be functionally classified into effector subsets on the basis of the production of signature cytokines, analogous to adaptive helper T cell subsets. However, unlike the function of adaptive T cells, γδ effector T cell function correlates with genomically encoded T cell antigen receptor (TCR) chains, which suggests that clonal TCR selection is not the main determinant of the differentiation of γδ effector cells. A high-resolution transcriptome analysis of all emergent γδ thymocyte subsets segregated on the basis of use of the TCR γ-chain or δ-chain indicated the existence of three separate subtypes of γδ effector cells in the thymus. The immature γδ subsets were distinguished by unique transcription-factor modules that program effector function.
Description
PMC 2012 November 01
Date issued
2012-04Department
Massachusetts Institute of Technology. Department of BiologyJournal
Nature Immunology
Publisher
Nature Publishing Group
Citation
Narayan, Kavitha, Katelyn E Sylvia, Nidhi Malhotra, Catherine C Yin, Gregory Martens, Therese Vallerskog, Hardy Kornfeld, et al. “Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes.” Nature Immunology 13, no. 5 (April 1, 2012): 511-518.
Version: Author's final manuscript
ISSN
1529-2908
1529-2916