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dc.contributor.authorYoung, Richard A.
dc.contributor.authorYoung, Richard A.
dc.date.accessioned2014-02-27T20:42:41Z
dc.date.available2014-02-27T20:42:41Z
dc.date.issued2011-03
dc.identifier.issn00928674
dc.identifier.urihttp://hdl.handle.net/1721.1/85177
dc.description.abstractEmbryonic stem cells and induced pluripotent stem cells hold great promise for regenerative medicine. These cells can be propagated in culture in an undifferentiated state but can be induced to differentiate into specialized cell types. Moreover, these cells provide a powerful model system for studies of cellular identity and early mammalian development. Recent studies have provided insights into the transcriptional control of embryonic stem cell state, including the regulatory circuitry underlying pluripotency. These studies have, as a consequence, uncovered fundamental mechanisms that control mammalian gene expression, connect gene expression to chromosome structure, and contribute to human disease.en_US
dc.language.isoen_US
dc.publisherElsevier B.V.en_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.cell.2011.01.032en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceElsevier Open Archiveen_US
dc.titleControl of the Embryonic Stem Cell Stateen_US
dc.typeArticleen_US
dc.identifier.citationYoung, Richard A. “Control of the Embryonic Stem Cell State.” Cell 144, no. 6 (March 2011): 940–954.© 2011 Elsevier Inc.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.mitauthorYoung, Richard A.en_US
dc.relation.journalCellen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsYoung, Richard A.en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-8855-8647
mit.licensePUBLISHER_POLICYen_US


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