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dc.contributor.authorFoti, James J.
dc.contributor.authorWalker, Graham C.
dc.date.accessioned2014-03-06T20:41:44Z
dc.date.available2014-03-06T20:41:44Z
dc.date.issued2010-04
dc.identifier.issn00928674
dc.identifier.urihttp://hdl.handle.net/1721.1/85549
dc.description.abstractDNA polymerases ensure the faithful duplication of genetic information inside the nuclease and mitochondria of eukaryotic cells and the nucleoid of prokaryotic cells. These remarkable enzymes synthesize polynucleotide chains based on the complementarity of an incoming nucleotide to an existing DNA template. DNA polymerases are grouped into six families (A, B, C, D, X, and Y). The previous SnapShot (DNA Polymerases I Prokaryotes) described the structural and functional characteristics conserved across the families, using the DNA polymerases from the bacterium Escherichia coli as an example. In this SnapShot, we now highlight DNA polymerases from humans (Homo sapiens) and their relationship to human diseases. However, this list is certainly not exhaustive, and the number of putative links between DNA polymerases and diseases continues to grow.en_US
dc.language.isoen_US
dc.publisherElsevier B.V.en_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.cell.2010.04.005en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceElsevier Open Archiveen_US
dc.titleSnapShot: DNA Polymerases II Mammalsen_US
dc.typeArticleen_US
dc.identifier.citationFoti, James J., and Graham C. Walker. “SnapShot: DNA Polymerases II Mammals.” Cell 141, no. 2 (April 2010): 370–370.e1.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorFoti, James J.en_US
dc.contributor.mitauthorWalker, Graham C.en_US
dc.relation.journalCellen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsFoti, James J.; Walker, Graham C.en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-7243-8261
mit.licensePUBLISHER_POLICYen_US


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