MicroRNA Functions in Stress Responses

Author(s)
Leung, Anthony; Sharp, Phillip A.
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Abstract
MicroRNAs (miRNAs) are a class of ~22 nucleotide short noncoding RNAs that play key roles in fundamental cellular processes, including how cells respond to changes in environment or, broadly defined, stresses. Responding to stresses, cells either choose to restore or reprogram their gene expression patterns. This decision is partly mediated by miRNA functions, in particular by modulating the amount of miRNAs, the amount of mRNA targets, or the activity/mode of action of miRNA-protein complexes. In turn, these changes determine the specificity, timing, and concentration of gene products expressed upon stresses. Dysregulation of these processes contributes to chronic diseases, including cancers.
Date issued
2010-10
URI
http://hdl.handle.net/1721.1/85552
Department
Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Journal
Molecular Cell
Publisher
Elsevier B.V.
Citation
Leung, Anthony K.L., and Phillip A. Sharp. “MicroRNA Functions in Stress Responses.” Molecular Cell 40, no. 2 (October 2010): 205-215.
Version: Final published version
ISSN
10972765
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