Induction and molecular signature of pathogenic T[subscript H]17 cells
Author(s)Lee, Youjin; Awasthi, Amit; Yosef, Nir; Quintana, Francisco J.; Xiao, Sheng; Peters, Anneli; Wu, Chuan; Kleinewietfeld, Markus; Kunder, Sharon; Hafler, David A.; Sobel, Raymond A.; Regev, Aviv; Kuchroo, Vijay K.; ... Show more Show less
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Interleukin 17 (IL-17)-producing helper T cells (T[subscript H]17 cells) are often present at the sites of tissue inflammation in autoimmune diseases, which has led to the conclusion that T[subscript H]17 cells are main drivers of autoimmune tissue injury. However, not all T[subscript H]17 cells are pathogenic; in fact, T[subscript H]17 cells generated with transforming growth factor-β1 (TGF-β1) and IL-6 produce IL-17 but do not readily induce autoimmune disease without further exposure to IL-23. Here we found that the production of TGF-β3 by developing T[subscript H]17 cells was dependent on IL-23, which together with IL-6 induced very pathogenic T[subscript H]17 cells. Moreover, TGF-β3-induced T[subscript H]17 cells were functionally and molecularly distinct from TGF-β1-induced T[subscript H]17 cells and had a molecular signature that defined pathogenic effector T[subscript H]17 cells in autoimmune disease.
DepartmentMassachusetts Institute of Technology. Department of Biology
Nature Publishing Group
Lee, Youjin, Amit Awasthi, Nir Yosef, Francisco J Quintana, Sheng Xiao, Anneli Peters, Chuan Wu, et al. “Induction and molecular signature of pathogenic TH17 cells.” Nature Immunology 13, no. 10 (September 9, 2012): 991-999.
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