Molecular definition of the identity and activation of natural killer cells
Author(s)Bezman, Natalie A.; Kim, Charles C.; Sun, Joseph C.; Min-Oo, Gundula; Hendricks, Deborah W.; Kamimura, Yosuke; Best, J. Adam; Goldrath, Ananda W.; Lanier, Lewis L.; Regev, Aviv; Immunological Genome Project Consortium; ... Show more Show less
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Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cells are known to share expression of a few genes with cytotoxic CD8+ T cells, our transcriptome-wide analysis demonstrates that the commonalities extend to hundreds of genes, many encoding molecules with unknown functions. Resting NK cells demonstrate a 'preprimed' state compared with naive T cells, which allows NK cells to respond more rapidly to viral infection. Collectively, our data provide a global context for known and previously unknown molecular aspects of NK cell identity and function by delineating the genome-wide repertoire of gene expression of NK cells in various states.
available in PMC 2013 April 01.
DepartmentMassachusetts Institute of Technology. Department of Biology
Bezman, Natalie A, Charles C Kim, Joseph C Sun, Gundula Min-Oo, Deborah W Hendricks, Yosuke Kamimura, J Adam Best, et al. “Molecular definition of the identity and activation of natural killer cells.” Nature Immunology 13, no. 10 (August 19, 2012): 1000-1009.
Author's final manuscript