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dc.contributor.authorGavino, Michael A.
dc.contributor.authorWenemoser, Danielle
dc.contributor.authorWang, Irving E.
dc.contributor.authorReddien, Peter
dc.date.accessioned2014-03-20T16:23:33Z
dc.date.available2014-03-20T16:23:33Z
dc.date.issued2013-09
dc.identifier.issn2050-084X
dc.identifier.urihttp://hdl.handle.net/1721.1/85849
dc.description.abstractRegeneration is widespread, but mechanisms that activate regeneration remain mysterious. Planarians are capable of whole-body regeneration and mount distinct molecular responses to wounds that result in tissue absence and those that do not. A major question is how these distinct responses are activated. We describe a follistatin homolog (Smed-follistatin) required for planarian regeneration. Smed-follistatin inhibition blocks responses to tissue absence but does not prevent normal tissue turnover. Two activin homologs (Smed-activin-1 and Smed-activin-2) are required for the Smed-follistatin phenotype. Finally, Smed-follistatin is wound-induced and expressed at higher levels following injuries that cause tissue absence. These data suggest that Smed-follistatin inhibits Smed-Activin proteins to trigger regeneration specifically following injuries involving tissue absence and identify a mechanism critical for regeneration initiation, a process important across the animal kingdom.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH (R01GM080639))en_US
dc.description.sponsorshipW. M. Keck Foundationen_US
dc.description.sponsorshipHoward Hughes Medical Institute (Early career scientist)en_US
dc.language.isoen_US
dc.publishereLife Sciences Publications, Ltd.en_US
dc.relation.isversionofhttp://dx.doi.org/10.7554/eLife.00247en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en_US
dc.sourceeLifeen_US
dc.titleTissue absence initiates regeneration through Follistatin-mediated inhibition of Activin signalingen_US
dc.typeArticleen_US
dc.identifier.citationGavino, M. A., D. Wenemoser, I. E. Wang, and P. W. Reddien. “Tissue Absence Initiates Regeneration through Follistatin-Mediated Inhibition of Activin Signaling.” eLife 2, no. 0 (September 10, 2013): e00247–e00247.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.mitauthorWang, Irving E.en_US
dc.contributor.mitauthorGavino, Michael A.en_US
dc.contributor.mitauthorWenemoser, Danielleen_US
dc.contributor.mitauthorReddien, Peteren_US
dc.relation.journaleLifeen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsGaviño, Michael A; Wenemoser, Danielle; Wang, Irving E; Reddien, Peter Wen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-5569-333X
mit.licensePUBLISHER_CCen_US


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