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dc.contributor.authorSander, Christin Yen-Ming
dc.contributor.authorRosen, Bruce R.
dc.contributor.authorHooker, Jacob M.
dc.contributor.authorCatana, Ciprian
dc.contributor.authorNormandin, Marc D.
dc.contributor.authorAlpert, Nathaniel M.
dc.contributor.authorKnudsen, Gitte M.
dc.contributor.authorVanduffel, Wim
dc.contributor.authorMandeville, Joseph B.
dc.date.accessioned2014-03-24T16:48:46Z
dc.date.available2014-03-24T16:48:46Z
dc.date.issued2013-07
dc.date.submitted2012-12
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/1721.1/85908
dc.description.abstractThis study employed simultaneous neuroimaging with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to demonstrate the relationship between changes in receptor occupancy measured by PET and changes in brain activity inferred by fMRI. By administering the D2/D3 dopamine receptor antagonist [[superscript 11]C]raclopride at varying specific activities to anesthetized nonhuman primates, we mapped associations between changes in receptor occupancy and hemodynamics [cerebral blood volume (CBV)] in the domains of space, time, and dose. Mass doses of raclopride above tracer levels caused increases in CBV and reductions in binding potential that were localized to the dopamine-rich striatum. Moreover, similar temporal profiles were observed for specific binding estimates and changes in CBV. Injection of graded raclopride mass doses revealed a monotonic coupling between neurovascular responses and receptor occupancies. The distinct CBV magnitudes between putamen and caudate at matched occupancies approximately matched literature differences in basal dopamine levels, suggesting that the relative fMRI measurements reflect basal D2/D3 dopamine receptor occupancy. These results can provide a basis for models that relate dopaminergic occupancies to hemodynamic changes in the basal ganglia. Overall, these data demonstrate the utility of simultaneous PET/fMRI for investigations of neurovascular coupling that correlate neurochemistry with hemodynamic changes in vivo for any receptor system with an available PET tracer.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R90DA023427)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant P41RR14075)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant P30DA28800)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant S10RR026666)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant S10RR017208)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant S10RR022976)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant S10RR019933)en_US
dc.language.isoen_US
dc.publisherNational Academy of Sciences (U.S.)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1073/pnas.1220512110en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceNational Academy of Science (U.S.)en_US
dc.titleNeurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRIen_US
dc.typeArticleen_US
dc.identifier.citationSander, C. Y., J. M. Hooker, C. Catana, M. D. Normandin, N. M. Alpert, G. M. Knudsen, W. Vanduffel, B. R. Rosen, and J. B. Mandeville. “Neurovascular Coupling to D2/D3 Dopamine Receptor Occupancy Using Simultaneous PET/functional MRI.” Proceedings of the National Academy of Sciences 110, no. 27 (July 2, 2013): 11169–11174.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.mitauthorSander, Christin Yen-Mingen_US
dc.contributor.mitauthorRosen, Bruce R.en_US
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsSander, C. Y.; Hooker, J. M.; Catana, C.; Normandin, M. D.; Alpert, N. M.; Knudsen, G. M.; Vanduffel, W.; Rosen, B. R.; Mandeville, J. B.en_US
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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