Polo kinase Cdc5 is a central regulator of meiosis I
Author(s)Attner, Michelle Andrea; Ee, Ly-sha; Elkin, Sheryl K.; Amon, Angelika B.; Miller, Matthew P., Ph. D. (Matthew Paul). Massachusetts Institute of Technology
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During meiosis, two consecutive rounds of chromosome segregation yield four haploid gametes from one diploid cell. The Polo kinase Cdc5 is required for meiotic progression, but how Cdc5 coordinates multiple cell-cycle events during meiosis I is not understood. Here we show that CDC5-dependent phosphorylation of Rec8, a subunit of the cohesin complex that links sister chromatids, is required for efficient cohesin removal from chromosome arms, which is a prerequisite for meiosis I chromosome segregation. CDC5 also establishes conditions for centromeric cohesin removal during meiosis II by promoting the degradation of Spo13, a protein that protects centromeric cohesin during meiosis I. Despite CDC5’s central role in meiosis I, the protein kinase is dispensable during meiosis II and does not even phosphorylate its meiosis I targets during the second meiotic division. We conclude that Cdc5 has evolved into a master regulator of the unique meiosis I chromosome segregation pattern.
DepartmentMassachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Proceedings of the National Academy of Sciences
National Academy of Sciences (U.S.)
Attner, M. A., M. P. Miller, L.-s. Ee, S. K. Elkin, and A. Amon. “Polo Kinase Cdc5 Is a Central Regulator of Meiosis I.” Proceedings of the National Academy of Sciences 110, no. 35 (August 27, 2013): 14278–14283.
Final published version