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Photocrosslinkable Kappa-Carrageenan Hydrogels for Tissue Engineering Applications

Author(s)
Mihaila, Silvia M.; Reis, Rui L.; Marques, Alexandra P.; Gomes, Manuela E.; Khademhosseini, Ali; Gaharwar, Akhilesh; ... Show more Show less
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Abstract
Kappa carrageenan (κ-CA) is a natural-origin polymer that closely mimics the glycosaminoglycan structure, one of the most important constituents of native tissues extracellular matrix. Previously, it has been shown that κ-CA can crosslink via ionic interactions rendering strong, but brittle hydrogels. In this study, we introduce photocrosslinkable methacrylate moieties on the κ-CA backbone to create physically and chemically crosslinked hydrogels highlighting their use in the context of tissue engineering. By varying the degree of methacrylation, the effect on hydrogel crosslinking was investigated in terms of hydration degree, dissolution profiles, morphological, mechanical, and rheological properties. Furthermore, the viability of fibroblast cells cultured inside the photocrosslinked hydrogels was investigated. The combination of chemical and physical crosslinking procedures enables the formation of hydrogels with highly versatile physical and chemical properties, while maintaining the viability of encapsulated cells. To our best knowledge, this is the first study reporting the synthesis of photocrosslinkable κ-CA with controllable compressive moduli, swelling ratios and pore size distributions. Moreover, by micromolding approaches, spatially controlled geometries and cell distribution patterns could be obtained, thus enabling the development of cell-material platforms that can be applied and tailored to a broad range of tissue engineering strategies.
Date issued
2013-06
URI
http://hdl.handle.net/1721.1/85930
Department
Harvard University--MIT Division of Health Sciences and Technology; Koch Institute for Integrative Cancer Research at MIT
Journal
Advanced Healthcare Materials
Publisher
John Wiley & Sons, Inc
Citation
Mihaila, Silvia M., Akhilesh K. Gaharwar, Rui L. Reis, Alexandra P. Marques, Manuela E. Gomes, and Ali Khademhosseini. “ Photocrosslinkable Kappa -Carrageenan Hydrogels for Tissue Engineering Applications .” Advanced Healthcare Materials 2, no. 6 (June 2013): 895–907.
Version: Author's final manuscript
ISSN
21922640

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