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Quantitative oxygenation venography from MRI phase

Author(s)
Fan, Audrey Peiwen; Bilgic, Berkin; Gagnon, Louis; Witzel, Thomas; Bhat, Himanshu; Rosen, Bruce R.; Adalsteinsson, Elfar; ... Show more Show less
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Abstract
Purpose To demonstrate acquisition and processing methods for quantitative oxygenation venograms that map in vivo oxygen saturation (SvO2) along cerebral venous vasculature. Methods Regularized quantitative susceptibility mapping (QSM) is used to reconstruct susceptibility values and estimate SvO2 in veins. QSM with ℓ1 and ℓ2 regularization are compared in numerical simulations of vessel structures with known magnetic susceptibility. Dual-echo, flow-compensated phase images are collected in three healthy volunteers to create QSM images. Bright veins in the susceptibility maps are vectorized and used to form a three-dimensional vascular mesh, or venogram, along which to display SvO2 values from QSM. Results Quantitative oxygenation venograms that map SvO2 along brain vessels of arbitrary orientation and geometry are shown in vivo. SvO2 values in major cerebral veins lie within the normal physiological range reported by 15O positron emission tomography. SvO2 from QSM is consistent with previous MR susceptometry methods for vessel segments oriented parallel to the main magnetic field. In vessel simulations, ℓ1 regularization results in less than 10% SvO2 absolute error across all vessel tilt orientations and provides more accurate SvO2 estimation than ℓ2 regularization. Conclusion The proposed analysis of susceptibility images enables reliable mapping of quantitative SvO2 along venograms and may facilitate clinical use of venous oxygenation imaging.
Date issued
2013-09
URI
http://hdl.handle.net/1721.1/85931
Department
Massachusetts Institute of Technology. Magnetic Resonance Imaging Group; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Research Laboratory of Electronics
Journal
Magnetic Resonance in Medicine
Publisher
John Wiley & Sons, Inc
Citation
Fan, Audrey P., Berkin Bilgic, Louis Gagnon, Thomas Witzel, Himanshu Bhat, Bruce R. Rosen, and Elfar Adalsteinsson. "Quantitative oxygenation venography from MRI phase." Magnetic Resonance in Medicine, early view version (4 Sep 2013).
Version: Author's final manuscript
ISSN
07403194

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