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dc.contributor.authorKaguni, Jon M.
dc.contributor.authorBell, Stephen P
dc.date.accessioned2014-04-03T15:36:28Z
dc.date.available2014-04-03T15:36:28Z
dc.date.issued2013-04
dc.identifier.issn1943-0264
dc.identifier.urihttp://hdl.handle.net/1721.1/85990
dc.description.abstractLoading of the replicative DNA helicase at origins of replication is of central importance in DNA replication. As the first of the replication fork proteins assemble at chromosomal origins of replication, the loaded helicase is required for the recruitment of the rest of the replication machinery. In this work, we review the current knowledge of helicase loading at Escherichia coli and eukaryotic origins of replication. In each case, this process requires both an origin recognition protein as well as one or more additional proteins. Comparison of these events shows intriguing similarities that suggest a similar underlying mechanism, as well as critical differences that likely reflect the distinct processes that regulate helicase loading in bacterial and eukaryotic cells.en_US
dc.description.sponsorshipHoward Hughes Medical Instituteen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant RO1 GM052339)en_US
dc.language.isoen_US
dc.publisherCold Spring Harbor Laboratory Pressen_US
dc.relation.isversionofhttp://dx.doi.org/10.1101/cshperspect.a010124en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourceBell via Courtney Crummetten_US
dc.titleHelicase Loading at Chromosomal Origins of Replicationen_US
dc.typeArticleen_US
dc.identifier.citationBell, S. P., and J. M. Kaguni. “Helicase Loading at Chromosomal Origins of Replication.” Cold Spring Harbor Perspectives in Biology 5, no. 6 (June 1, 2013): a010124–a010124.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.approverBell, Stephen P.en_US
dc.contributor.mitauthorBell, Stephen P.en_US
dc.relation.journalCold Spring Harbor Perspectives in Biologyen_US
dc.eprint.versionOriginal manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/NonPeerRevieweden_US
dspace.orderedauthorsBell, S. P.; Kaguni, J. M.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-2876-610X
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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