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Mo-Based Complexes with Two Aryloxides and a Pentafluoroimido Ligand: Catalysts for Efficient Z-Selective Synthesis of a Macrocyclic Trisubstituted Alkene by Ring-Closing Metathesis

dc.contributor.authorWang, Chenbo
dc.contributor.authorHaeffner, Fredrik
dc.contributor.authorHoveyda, Amir H.
dc.contributor.authorSchrock, Richard Royce
dc.date.accessioned2014-04-11T13:28:49Z
dc.date.available2014-04-11T13:28:49Z
dc.date.issued2013-01
dc.date.submitted2012-11
dc.identifier.issn14337851
dc.identifier.issn1521-3773
dc.identifier.urihttp://hdl.handle.net/1721.1/86095
dc.description.abstractOlefin metathesis catalysts for controlling the formation of trisubstituted macrocyclic Z alkenes have been developed. The most effective complexes are Mo alkylidenes with a pentafluorophenylimido group and two large aryloxide ligands. The macrocyclic lactone precursor to anticancer agents epothilones B and D is obtained in 73% yield and 91% Z selectivity in less than 6 hours at room temperature.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (GM-59426)en_US
dc.language.isoen_US
dc.publisherWiley Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/anie.201209180en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourceProf. Schrock via Erja Kajosaloen_US
dc.titleMo-Based Complexes with Two Aryloxides and a Pentafluoroimido Ligand: Catalysts for Efficient Z-Selective Synthesis of a Macrocyclic Trisubstituted Alkene by Ring-Closing Metathesisen_US
dc.title.alternativeMolybdenum-Based Complexes with Two Aryloxides and a Pentafluoroimido Ligand: Catalysts for Efficient Z-Selective Synthesis of a Macrocyclic Trisubstituted Alkene by Ring-Closing Metathesisen_US
dc.typeArticleen_US
dc.identifier.citationWang, Chenbo, Fredrik Haeffner, Richard R. Schrock, and Amir H. Hoveyda. “Molybdenum-Based Complexes with Two Aryloxides and a Pentafluoroimido Ligand: Catalysts for Efficient Z -Selective Synthesis of a Macrocyclic Trisubstituted Alkene by Ring-Closing Metathesis.” Angewandte Chemie International Edition 52, no. 7 (February 11, 2013): 1939–1943.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorSchrock, Richard Royceen_US
dc.relation.journalAngewandte Chemie International Editionen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsWang, Chenbo; Haeffner, Fredrik; Schrock, Richard R.; Hoveyda, Amir H.en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-5827-3552
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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