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The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer

dc.contributor.authorMurchison, Elizabeth P.
dc.contributor.authorTovar, Cesar
dc.contributor.authorHsu, Arthur
dc.contributor.authorBender, Hannah S.
dc.contributor.authorKheradpour, Pouya
dc.contributor.authorRebbeck, Clare A.
dc.contributor.authorObendorf, David
dc.contributor.authorConlan, Carly
dc.contributor.authorBahlo, Melanie
dc.contributor.authorBlizzard, Catherine A.
dc.contributor.authorPyecroft, Stephen
dc.contributor.authorKreiss, Alexandre
dc.contributor.authorKellis, Manolis
dc.contributor.authorStark, Alexander
dc.contributor.authorHarkins, Timothy T.
dc.contributor.authorGraves, Jennifer A. Marshall
dc.contributor.authorWoods, Gregory M.
dc.contributor.authorHannon, Gregory J.
dc.contributor.authorPapenfuss, Anthony T.
dc.date.accessioned2014-05-14T21:20:11Z
dc.date.available2014-05-14T21:20:11Z
dc.date.issued2009-12
dc.date.submitted2009-08
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.urihttp://hdl.handle.net/1721.1/86961
dc.description.abstractThe Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.en_US
dc.description.sponsorshipAmerican Australian Associationen_US
dc.description.sponsorshipAustralian National Health and Medical Councilen_US
dc.description.sponsorshipHuman Frontier Science Program (Strasbourg, France) (Fellowship)en_US
dc.description.sponsorshipAustralian Research Council (Linkage Grant (LP0562190))en_US
dc.description.sponsorshipDr. Eric Guiler Tasmanian Devil Research Grantsen_US
dc.language.isoen_US
dc.publisherAmerican Association for the Advancement of Science (AAAS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1126/science.1180616en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titleThe Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Canceren_US
dc.typeArticleen_US
dc.identifier.citationMurchison, E. P., C. Tovar, A. Hsu, H. S. Bender, P. Kheradpour, C. A. Rebbeck, D. Obendorf, et al. “The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer.” Science 327, no. 5961 (January 1, 2010): 84–87.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratoryen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.mitauthorKheradpour, Pouyaen_US
dc.contributor.mitauthorKellis, Manolisen_US
dc.contributor.mitauthorStark, Alexanderen_US
dc.relation.journalScienceen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsMurchison, E. P.; Tovar, C.; Hsu, A.; Bender, H. S.; Kheradpour, P.; Rebbeck, C. A.; Obendorf, D.; Conlan, C.; Bahlo, M.; Blizzard, C. A.; Pyecroft, S.; Kreiss, A.; Kellis, M.; Stark, A.; Harkins, T. T.; Graves, J. A. M.; Woods, G. M.; Hannon, G. J.; Papenfuss, A. T.en_US
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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