The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse
Author(s)
Grote, Phillip; Wittler, Lars; Hendrix, David A.; Koch, Frederic; Beisaw, Arica; Macura, Karol; Kellis, Manolis; Werber, Martin; Herrmann, Bernhard G.; Wahrisch, Sandra; Blass, Gaby; ... Show more Show less
DownloadKellis_The tissue-specific.pdf (3.467Mb)
PUBLISHER_POLICY
Publisher Policy
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Terms of use
Metadata
Show full item recordAbstract
The histone-modifying complexes PRC2 and TrxG/MLL play pivotal roles in determining the activation state of genes controlling pluripotency, lineage commitment, and cell differentiation. Long noncoding RNAs (lncRNAs) can bind to either complex, and some have been shown to act as modulators of PRC2 or TrxG/MLL activity. Here we show that the lateral mesoderm-specific lncRNA Fendrr is essential for proper heart and body wall development in the mouse. Embryos lacking Fendrr displayed upregulation of several transcription factors controlling lateral plate or cardiac mesoderm differentiation, accompanied by a drastic reduction in PRC2 occupancy along with decreased H3K27 trimethylation and/or an increase in H3K4 trimethylation at their promoters. Fendrr binds to both the PRC2 and TrxG/MLL complexes, suggesting that it acts as modulator of chromatin signatures that define gene activity. Thus, we identified an lncRNA that plays an essential role in the regulatory networks controlling the fate of lateral mesoderm derivatives.
Date issued
2013-01Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer ScienceJournal
Developmental Cell
Publisher
Elsevier
Citation
Grote, Phillip, Lars Wittler, David Hendrix, Frederic Koch, Sandra Wahrisch, Arica Beisaw, Karol Macura, et al. “The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse.” Developmental Cell 24, no. 2 (January 2013): 206–214. © 2013 Elsevier Inc.
Version: Final published version
ISSN
15345807
1878-1551