Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies
Author(s)Szkulmowski, Maciej; Wojtkowski, Maciej; Sikorski, Bartosz; Bajraszewski, Tomasz; Srinivasan, Vivek J.; Szkulmowska, Anna; Kaluzny, Jakub J.; Fujimoto, James G.; Kowalczyk, Andrzej; ... Show more Show less
MetadataShow full item record
We present a computationally efficient, semiautomated method for analysis of posterior retinal layers in three-dimensional (3-D) images obtained by spectral optical coherence tomography (SOCT). The method consists of two steps: segmentation of posterior retinal layers and analysis of their thickness and distance from an outer retinal contour (ORC), which is introduced to approximate the normal position of external interface of the healthy retinal pigment epithelium (RPE). The algorithm is shown to effectively segment posterior retina by classifying every pixel in the SOCT tomogram using the similarity of its surroundings to a reference set of model pixels from user-selected area(s). Operator intervention is required to assess the quality of segmentation. Thickness and distance maps from the segmented layers and their analysis are presented for healthy and pathological retinas.
DepartmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Research Laboratory of Electronics
Journal of Biomedical Optics
Szkulmowski, Maciej, Maciej Wojtkowski, Bartosz Sikorski, Tomasz Bajraszewski, Vivek J. Srinivasan, Anna Szkulmowska, Jakub J. Kaluzny, James G. Fujimoto, and Andrzej Kowalczyk. “Analysis of Posterior Retinal Layers in Spectral Optical Coherence Tomography Images of the Normal Retina and Retinal Pathologies.” Journal of Biomedical Optics 12, no. 4 (2007): 041207. © 2007 Society of Photo-Optical Instrumentation Engineers
Final published version