Gut Microbiota and the Paradox of Cancer Immunotherapy
Author(s)Poutahidis, Theofilos; Kleinewietfeld, Markus; Erdman, Susan E.
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It is recently shown that beneficial environmental microbes stimulate integrated immune and neuroendocrine factors throughout the body, consequently modulating regulatory T-lymphocyte phenotypes, maintaining systemic immune balance, and determining the fate of preneoplastic lesions toward regression while sustaining whole body good health. Stimulated by a gut microbiota-centric systemic homeostasis hypothesis, we set out to explore the influence of the gut microbiome to explain the paradoxical roles of regulatory T-lymphocytes in cancer development and growth. This paradigm shift places cancer prevention and treatment into a new broader context of holobiont engineering to cultivate a tumor-suppressive macroenvironment.
DepartmentMassachusetts Institute of Technology. Division of Comparative Medicine
Frontiers in Immunology
Frontiers Research Foundation
Poutahidis, Theofilos, Markus Kleinewietfeld, and Susan E. Erdman. “Gut Microbiota and the Paradox of Cancer Immunotherapy.” Front. Immunol. 5 (April 7, 2014).
Final published version