Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies
Author(s)New, Roger; Bansal, Gurpal; Bogus, Michael; Zajkowska, Kasia; Rickelt, Steffen; Toth, Istvan; ... Show more Show less
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We describe a new method of combinatorial screening in which building blocks, instead of being linked together chemically, are placed on the surface of nanoparticles. Two- or three-dimensional structures form on the surface of these particles through the close approach of different building blocks, with sufficient flexibility to be able to adapt and interact with putative binding sites in biological systems. The particles assemble without the need for formation of chemical bonds, so libraries comprised of many structures can be prepared rapidly, with large quantities of material available for testing. Screening methods can include solid and solution-phase binding assays, or tissue culture models, for example looking for structures which can change the behaviour of cells in a disease-modifying manner.
DepartmentKoch Institute for Integrative Cancer Research at MIT
New, Roger, Gurpal Bansal, Michael Bogus, Kasia Zajkowska, Steffen Rickelt, and Istvan Toth. “Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies.” Molecules 18, no. 3 (March 14, 2013): 3427–3441.
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