Multiscale fingerprinting of neuronal functional connectivity
Author(s)Song, Gang; Tin, Chung; Poon, Chi-Sang
MetadataShow full item record
Current cellular-based connectomics approaches aim to delineate the functional or structural organizations of mammalian brain circuits through neuronal activity mapping and/or axonal tracing. To discern possible connectivity between functionally identified neurons in widely distributed brain circuits, reliable and efficient network-based approaches of cross-registering or cross-correlating such functional-structural data are essential. Here, a novel cross-correlation approach that exploits multiple timing-specific, response-specific and cell-specific neuronal characteristics as coincident fingerprint markers at the systems, network and cellular levels is proposed. Application of this multiscale temporal-cellular coincident fingerprinting assay to the respiratory central pattern generator network in rats revealed a descending excitatory pathway with characteristic activity pattern and projecting from a distinct neuronal population in pons to its counterparts in medulla that control the post-inspiratory phase of the respiratory rhythm important for normal breathing, airway protection and respiratory-vocalization coordination. This enabling neurotracing approach may prove valuable for functional connectivity mapping of other brain circuits.
DepartmentMassachusetts Institute of Technology. Institute for Medical Engineering & Science
Brain Structure and Function
Song, Gang, Chung Tin, and Chi-Sang Poon. "Multiscale fingerprinting of neuronal functional connectivity." Brain Structure and Function, December 2014.
Author's final manuscript