Multiscale fingerprinting of neuronal functional connectivity
Name
88126.pdf
Description
Multiscale fingerprinting of neuronal functional connectivity
Size
1.53 MB
Format
Adobe PDF
Checksum (MD5)
4917ad08bf07409fff2ee40173744af3
Author(s)
Song, Gang
Tin, Chung
Poon, Chi-Sang
Date Issued
December 2014
Journal
Brain Structure and Function
Publisher
Springer-Verlag
Citation
Song, Gang, Chung Tin, and Chi-Sang Poon. "Multiscale fingerprinting of neuronal functional connectivity." Brain Structure and Function, December 2014.
Version
Author's final manuscript
Abstract
Current cellular-based connectomics approaches aim to delineate the functional or structural organizations of mammalian brain circuits through neuronal activity mapping and/or axonal tracing. To discern possible connectivity between functionally identified neurons in widely distributed brain circuits, reliable and efficient network-based approaches of cross-registering or cross-correlating such functional-structural data are essential. Here, a novel cross-correlation approach that exploits multiple timing-specific, response-specific and cell-specific neuronal characteristics as coincident fingerprint markers at the systems, network and cellular levels is proposed. Application of this multiscale temporal-cellular coincident fingerprinting assay to the respiratory central pattern generator network in rats revealed a descending excitatory pathway with characteristic activity pattern and projecting from a distinct neuronal population in pons to its counterparts in medulla that control the post-inspiratory phase of the respiratory rhythm important for normal breathing, airway protection and respiratory-vocalization coordination. This enabling neurotracing approach may prove valuable for functional connectivity mapping of other brain circuits.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
http://dx.doi.org/10.1007/s00429-014-0838-1
https://doi.org/10.1007/s00429-014-0838-1
