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dc.contributor.authorChang, Shu-Wei
dc.contributor.authorBuehler, Markus J.
dc.date.accessioned2014-07-08T18:24:49Z
dc.date.available2014-07-08T18:24:49Z
dc.date.issued2014-03
dc.identifier.issn13697021
dc.identifier.urihttp://hdl.handle.net/1721.1/88203
dc.description.abstractCollagenous tissues, made of collagen molecules, such as tendon and bone, are intriguing materials that have the ability to respond to mechanical forces by altering their structures from the molecular level up, and convert them into biochemical signals that control many biological and pathological processes such as wound healing and tissue remodeling. It is clear that collagen synthesis and degradation are influenced by mechanical loading, and collagenous tissues have a remarkable built-in ability to alter the equilibrium between material formation and breakdown. However, how the mechanical force alters structures of collagen molecules and how the structural changes affect collagen degradation at molecular level is not well understood. The purpose of this article is to review the biomechanics of collagen, using a bottom-up approach that begins with the mechanics of collagen molecules. The current understanding of collagen degradation mechanisms is presented, followed by a discussion of recent studies on how mechanical force mediates collagen breakdown. Understanding the biomechanics of collagen molecules will provide the basis for understanding the mechanobiology of collagenous tissues. Addressing challenges in this field provides an opportunity for developing treatments, designing synthetic collagen materials for a variety of biomedical applications, and creating a new class of ‘smart’ structural materials that autonomously grow when needed, and break down when no longer required, with applications in nanotechnology, devices and civil engineering.en_US
dc.description.sponsorshipNational Science Foundation (U.S.)en_US
dc.description.sponsorshipUnited States. Office of Naval Research. Presidential Early Career Award for Scientists and Engineersen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (U01EB014976)en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.mattod.2014.01.019en_US
dc.rightsCreative Commons Attribution Non-Commercial No-Derivativesen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en_US
dc.sourceElsevieren_US
dc.titleMolecular biomechanics of collagen moleculesen_US
dc.typeArticleen_US
dc.identifier.citationChang, Shu-Wei, and Markus J. Buehler. “Molecular Biomechanics of Collagen Molecules.” Materials Today 17, no. 2 (March 2014): 70–76. © 2014 Elsevier Ltd.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Center for Computational Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Civil and Environmental Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Materials Science and Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Laboratory for Atomistic and Molecular Mechanicsen_US
dc.contributor.mitauthorChang, Shu-Weien_US
dc.contributor.mitauthorBuehler, Markus J.en_US
dc.relation.journalMaterials Todayen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsChang, Shu-Wei; Buehler, Markus J.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-4173-9659
mit.licensePUBLISHER_CCen_US


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