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dc.contributor.authorTharakaraman, Kannan
dc.contributor.authorRaman, Rahul
dc.contributor.authorStebbins, Nathan W.
dc.contributor.authorViswanathan, Karthik
dc.contributor.authorSasisekharan, Viswanathan
dc.contributor.authorSasisekharan, Ram
dc.date.accessioned2014-07-08T21:04:58Z
dc.date.available2014-07-08T21:04:58Z
dc.date.issued2013-05
dc.date.submitted2012-12
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/1721.1/88223
dc.description.abstractThe 2009 swine-origin H1N1 influenza, though antigenically novel to the population at the time, was antigenically similar to the 1918 H1N1 pandemic influenza, and consequently was considered to be “archived” in the swine species before reemerging in humans. Given that the H3N2 is another subtype that currently circulates in the human population and is high on WHO pandemic preparedness list, we assessed the likelihood of reemergence of H3N2 from a non-human host. Using HA sequence features relevant to immune recognition, receptor binding and transmission we have identified several recent H3 strains in avian and swine that present hallmarks of a reemerging virus. IgG polyclonal raised in rabbit with recent seasonal vaccine H3 fail to recognize these swine H3 strains suggesting that existing vaccines may not be effective in protecting against these strains. Vaccine strategies can mitigate risks associated with a potential H3N2 pandemic in humans.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (R37 GM057073-13)en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/srep01822en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en_US
dc.sourceNature Publishing Groupen_US
dc.titleAntigenically intact hemagglutinin in circulating avian and swine influenza viruses and potential for H3N2 pandemicen_US
dc.typeArticleen_US
dc.identifier.citationTharakaraman, Kannan, Rahul Raman, Nathan W. Stebbins, Karthik Viswanathan, Viswanathan Sasisekharan, and Ram Sasisekharan. "Antigenically intact hemagglutinin in circulating avian and swine influenza viruses and potential for H3N2 pandemic." Scientific Reports 2, 2013, 1822.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorTharakaraman, Kannanen_US
dc.contributor.mitauthorRaman, Rahulen_US
dc.contributor.mitauthorStebbins, Nathan W.en_US
dc.contributor.mitauthorViswanathan, Karthiken_US
dc.contributor.mitauthorSasisekharan, Ramen_US
dc.contributor.mitauthorSasisekharan, Viswanathanen_US
dc.relation.journalScientific Reportsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsTharakaraman, Kannan; Raman, Rahul; Stebbins, Nathan W.; Viswanathan, Karthik; Sasisekharan, Viswanathan; Sasisekharan, Ramen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-1288-9965
dc.identifier.orcidhttps://orcid.org/0000-0002-2085-7840
dc.identifier.orcidhttps://orcid.org/0000-0002-6528-0125
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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