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dc.contributor.authorVelenich, Andrea
dc.contributor.authorGore, Jeff
dc.date.accessioned2014-07-24T19:35:58Z
dc.date.available2014-07-24T19:35:58Z
dc.date.issued2012-08
dc.identifier.issn13675931
dc.identifier.urihttp://hdl.handle.net/1721.1/88494
dc.description.abstractMicrobes can be readily cultured and their genomes can be easily manipulated. For these reasons, laboratory systems of unicellular organisms are increasingly used to develop and test theories about biological constraints, which manifest themselves at different levels of biological organization, from optimal gene-expression levels to complex individual and social behaviors. The quantitative description of biological constraints has recently advanced in several areas, such as the formulation of global laws governing the entire economy of a cell, the direct experimental measurement of the trade-offs leading to optimal gene expression, the description of naturally occurring fitness landscapes, and the appreciation of the requirements for a stable bacterial ecosystem.en_US
dc.description.sponsorshipAlfred P. Sloan Foundation (Fellowship)en_US
dc.description.sponsorshipPew Charitable Trusts (Pew Scholars Program)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (NSF CAREER Award)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH R00 Pathway to Independence Award)en_US
dc.language.isoen_US
dc.publisherElsevier B.V.en_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.cbpa.2012.05.199en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleSynthetic approaches to understanding biological constraintsen_US
dc.typeArticleen_US
dc.identifier.citationVelenich, Andrea, and Jeff Gore. “Synthetic Approaches to Understanding Biological Constraints.” Current Opinion in Chemical Biology 16, no. 3–4 (August 2012): 323–328.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Physicsen_US
dc.contributor.mitauthorGore, Jeffen_US
dc.contributor.mitauthorVelenich, Andreaen_US
dc.relation.journalCurrent Opinion in Chemical Biologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsVelenich, Andrea; Gore, Jeffen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-4583-8555
mit.licenseOPEN_ACCESS_POLICYen_US


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