MIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids

Author(s)
Cadet, Jean; Loft, Steffen; Olinski, Ryszard; Evans, Mark D.; Bialkowski, Karol; Richard Wagner, J.; Dedon, Peter C.; Moller, Peter; Greenberg, Marc M.; Cooke, Marcus S.; ... Show more Show less
Thumbnail
DownloadDedon_Biologically relevant.pdf (789.9Kb)
OPEN_ACCESS_POLICY

Open Access Policy

Creative Commons Attribution-Noncommercial-Share Alike

Terms of use
Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/
Metadata
Show full item record
Abstract
A broad scientific community is involved in investigations aimed at delineating the mechanisms of formation and cellular processing of oxidatively generated damage to nucleic acids. Perhaps as a consequence of this breadth of research expertise, there are nomenclature problems for several of the oxidized bases including 8-oxo-7,8-dihydroguanine (8-oxoGua), a ubiquitous marker of almost every type of oxidative stress in cells. Efforts to standardize the nomenclature and abbreviations of the main DNA degradation products that arise from oxidative pathways are reported. Information is also provided on the main oxidative radicals, non-radical oxygen species, one-electron agents and enzymes involved in DNA degradation pathways as well in their targets and reactivity. A brief classification of oxidatively generated damage to DNA that may involve single modifications, tandem base modifications, intrastrand and interstrand cross-links together with DNA-protein cross-links and base adducts arising from the addition of lipid peroxides breakdown products is also included.
Date issued
2012-04
URI
http://hdl.handle.net/1721.1/88780
Department
Massachusetts Institute of Technology. Department of Biological Engineering
Journal
Free Radical Research
Publisher
Informa UK (Informa Healthcare)
Citation
Cadet, Jean, Steffen Loft, Ryszard Olinski, Mark D. Evans, Karol Bialkowski, J. Richard Wagner, Peter C. Dedon, Peter Moller, Marc M. Greenberg, and Marcus S. Cooke. “Biologically Relevant Oxidants and Terminology, Classification and Nomenclature of Oxidatively Generated Damage to Nucleobases and 2-Deoxyribose in Nucleic Acids.” Free Radic Res 46, no. 4 (April 2012): 367–381.
Version: Author's final manuscript
ISSN
1071-5762
1029-2470

Collections
  • MIT Open Access Articles

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries
PrivacyPermissionsAccessibilityContact us
MIT
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.