Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids
Author(s)Cadet, Jean; Loft, Steffen; Olinski, Ryszard; Evans, Mark D.; Bialkowski, Karol; Richard Wagner, J.; Dedon, Peter C.; Moller, Peter; Greenberg, Marc M.; Cooke, Marcus S.; ... Show more Show less
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A broad scientific community is involved in investigations aimed at delineating the mechanisms of formation and cellular processing of oxidatively generated damage to nucleic acids. Perhaps as a consequence of this breadth of research expertise, there are nomenclature problems for several of the oxidized bases including 8-oxo-7,8-dihydroguanine (8-oxoGua), a ubiquitous marker of almost every type of oxidative stress in cells. Efforts to standardize the nomenclature and abbreviations of the main DNA degradation products that arise from oxidative pathways are reported. Information is also provided on the main oxidative radicals, non-radical oxygen species, one-electron agents and enzymes involved in DNA degradation pathways as well in their targets and reactivity. A brief classification of oxidatively generated damage to DNA that may involve single modifications, tandem base modifications, intrastrand and interstrand cross-links together with DNA-protein cross-links and base adducts arising from the addition of lipid peroxides breakdown products is also included.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering
Free Radical Research
Informa UK (Informa Healthcare)
Cadet, Jean, Steffen Loft, Ryszard Olinski, Mark D. Evans, Karol Bialkowski, J. Richard Wagner, Peter C. Dedon, Peter Moller, Marc M. Greenberg, and Marcus S. Cooke. “Biologically Relevant Oxidants and Terminology, Classification and Nomenclature of Oxidatively Generated Damage to Nucleobases and 2-Deoxyribose in Nucleic Acids.” Free Radic Res 46, no. 4 (April 2012): 367–381.
Author's final manuscript