Orientation-Specific Attachment of Polymeric Microtubes on Cell Surfaces

Author(s)
Gilbert, Jonathan Brian; O'Brien, Janice S.; Suresh, Harini S.; Cohen, Robert E.; Rubner, Michael F.
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Abstract
Tubular particles presenting heterogeneous regions of chemistry on the tube-ends versus the side are fabricated and are shown to control the particle orientation on the surface of live lymphocytes. Controlling the orientation of anisotropic microparticles on cell surfaces is of interest for biomedical applications and drug delivery in particular, since it can be used to promote or resist particle internalization.
Date issued
2013-11
URI
http://hdl.handle.net/1721.1/88976
Department
Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Department of Materials Science and Engineering
Journal
Advanced Materials
Publisher
WILEY-VCH Verlag GmbH & Co.
Citation
Gilbert, J. B., O'Brien, J. S., Suresh, H. S., Cohen, R. E. and Rubner, M. F. (2013), Orientation-Specific Attachment of Polymeric Microtubes on Cell Surfaces. Adv. Mater., 25: 5948–5952.
Version: Author's final manuscript
ISSN
09359648
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