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dc.contributor.authorMiller, Matthew P.
dc.contributor.authorUnal, Elcin
dc.contributor.authorBrar, Gloria A.
dc.contributor.authorAmon, Angelika B.
dc.date.accessioned2014-09-04T18:13:42Z
dc.date.available2014-09-04T18:13:42Z
dc.date.issued2012-12
dc.date.submitted2012-07
dc.identifier.issn2050-084X
dc.identifier.urihttp://hdl.handle.net/1721.1/89177
dc.description.abstractDuring meiosis, a single round of DNA replication is followed by two consecutive rounds of nuclear divisions called meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate, while sister chromatids remain together. Determining how this unusual chromosome segregation behavior is established is central to understanding germ cell development. Here we show that preventing microtubule–kinetochore interactions during premeiotic S phase and prophase I is essential for establishing the meiosis I chromosome segregation pattern. Premature interactions of kinetochores with microtubules transform meiosis I into a mitosis-like division by disrupting two key meiosis I events: coorientation of sister kinetochores and protection of centromeric cohesin removal from chromosomes. Furthermore we find that restricting outer kinetochore assembly contributes to preventing premature engagement of microtubules with kinetochores. We propose that inhibition of microtubule–kinetochore interactions during premeiotic S phase and prophase I is central to establishing the unique meiosis I chromosome segregation pattern.en_US
dc.description.sponsorshipHoward Hughes Medical Instituteen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (grant GM62207)en_US
dc.description.sponsorshipJane Coffin Childs Memorial Fund for Medical Researchen_US
dc.description.sponsorshipAmerican Cancer Societyen_US
dc.language.isoen_US
dc.publishereLife Sciences Publications, Ltd.en_US
dc.relation.isversionofhttp://dx.doi.org/10.7554/eLife.00117en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en_US
dc.sourceeLife Sciences Publications, Ltd.en_US
dc.titleMeiosis I chromosome segregation is established through regulation of microtubule–kinetochore interactionsen_US
dc.typeArticleen_US
dc.identifier.citationMiller, Matthew P, Elçin Ünal, Gloria A Brar, and Angelika Amon. “Meiosis I Chromosome Segregation Is Established through Regulation of Microtubule–kinetochore Interactions.” eLife;1:e00117 (December 18, 2012).en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorMiller, Matthew P.en_US
dc.contributor.mitauthorUnal, Elcinen_US
dc.contributor.mitauthorAmon, Angelika B.en_US
dc.relation.journaleLifeen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsMiller, Matthew P; Ünal, Elçin; Brar, Gloria A; Amon, Angelikaen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-2012-7546
dc.identifier.orcidhttps://orcid.org/0000-0001-9837-0314
mit.licensePUBLISHER_CCen_US


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