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dc.contributor.authorChen, Yuzhi
dc.contributor.authorNeve, Rachael L.
dc.contributor.authorLiu, Helena
dc.date.accessioned2014-09-09T19:13:42Z
dc.date.available2014-09-09T19:13:42Z
dc.date.issued2012-11
dc.date.submitted2012-02
dc.identifier.issn15821838
dc.identifier.urihttp://hdl.handle.net/1721.1/89400
dc.description.abstractUbiquitin-dependent proteolysis is a major mechanism that downregulates misfolded proteins or those that have finished a programmed task. In the last two decades, neddylation has emerged as a major regulatory pathway for ubiquitination. Central to the neddylation pathway is the amyloid precursor protein (APP)-binding protein APP-BP1, which together with Uba3, plays an analogous role to the ubiquitin-activating enzyme E1 in nedd8 activation. Activated nedd8 covalently modifies and activates a major class of ubiquitin ligases called Cullin-RING ligases (CRLs). New evidence suggests that neddylation also modifies Type-1 transmembrane receptors such as APP. Here we review the functions of neddylation and summarize evidence suggesting that dysfunction of neddylation is involved in Alzheimer's disease.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH/NIA RO1 AG034980)en_US
dc.language.isoen_US
dc.publisherJohn Wiley & Sons, Incen_US
dc.relation.isversionofhttp://dx.doi.org/10.1111/j.1582-4934.2012.01604.xen_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en_US
dc.sourceWiley Blackwellen_US
dc.titleNeddylation dysfunction in Alzheimer's diseaseen_US
dc.typeArticleen_US
dc.identifier.citationChen, Yuzhi, Rachael L. Neve, and Helena Liu. “Neddylation Dysfunction in Alzheimer’s Disease.” J. Cell. Mol. Med. 16, no. 11 (October 29, 2012): 2583–2591.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Materials Science and Engineeringen_US
dc.contributor.mitauthorNeve, Rachael L.en_US
dc.contributor.mitauthorLiu, Helenaen_US
dc.relation.journalJournal of Cellular and Molecular Medicineen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsChen, Yuzhi; Neve, Rachael L.; Liu, Helenaen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-3854-5968
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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