dc.contributor.author | Chen, Yuzhi | |
dc.contributor.author | Neve, Rachael L. | |
dc.contributor.author | Liu, Helena | |
dc.date.accessioned | 2014-09-09T19:13:42Z | |
dc.date.available | 2014-09-09T19:13:42Z | |
dc.date.issued | 2012-11 | |
dc.date.submitted | 2012-02 | |
dc.identifier.issn | 15821838 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/89400 | |
dc.description.abstract | Ubiquitin-dependent proteolysis is a major mechanism that downregulates misfolded proteins or those that have finished a programmed task. In the last two decades, neddylation has emerged as a major regulatory pathway for ubiquitination. Central to the neddylation pathway is the amyloid precursor protein (APP)-binding protein APP-BP1, which together with Uba3, plays an analogous role to the ubiquitin-activating enzyme E1 in nedd8 activation. Activated nedd8 covalently modifies and activates a major class of ubiquitin ligases called Cullin-RING ligases (CRLs). New evidence suggests that neddylation also modifies Type-1 transmembrane receptors such as APP. Here we review the functions of neddylation and summarize evidence suggesting that dysfunction of neddylation is involved in Alzheimer's disease. | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (NIH/NIA RO1 AG034980) | en_US |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1111/j.1582-4934.2012.01604.x | en_US |
dc.rights | Creative Commons Attribution | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/ | en_US |
dc.source | Wiley Blackwell | en_US |
dc.title | Neddylation dysfunction in Alzheimer's disease | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Chen, Yuzhi, Rachael L. Neve, and Helena Liu. “Neddylation Dysfunction in Alzheimer’s Disease.” J. Cell. Mol. Med. 16, no. 11 (October 29, 2012): 2583–2591. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Materials Science and Engineering | en_US |
dc.contributor.mitauthor | Neve, Rachael L. | en_US |
dc.contributor.mitauthor | Liu, Helena | en_US |
dc.relation.journal | Journal of Cellular and Molecular Medicine | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Chen, Yuzhi; Neve, Rachael L.; Liu, Helena | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-3854-5968 | |
mit.license | PUBLISHER_CC | en_US |
mit.metadata.status | Complete | |