MIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Systems analysis of the CO[subscript 2] concentrating mechanism in cyanobacteria

Author(s)
Mangan, Niall Mari; Brenner, Michael P.
Thumbnail
DownloadMangan-2014-Systems analysis of.pdf (1.871Mb)
PUBLISHER_CC

Publisher with Creative Commons License

Creative Commons Attribution

Alternative title
Systems analysis of the CO2 concentrating mechanism in cyanobacteria
Terms of use
Creative Commons Attribution http://creativecommons.org/licenses/by/3.0/
Metadata
Show full item record
Abstract
Cyanobacteria are photosynthetic bacteria with a unique CO2 concentrating mechanism (CCM), enhancing carbon fixation. Understanding the CCM requires a systems level perspective of how molecular components work together to enhance CO2 fixation. We present a mathematical model of the cyanobacterial CCM, giving the parameter regime (expression levels, catalytic rates, permeability of carboxysome shell) for efficient carbon fixation. Efficiency requires saturating the RuBisCO reaction, staying below saturation for carbonic anhydrase, and avoiding wasteful oxygenation reactions. We find selectivity at the carboxysome shell is not necessary; there is an optimal non-specific carboxysome shell permeability. We compare the efficacy of facilitated CO2 uptake, CO2 scavenging, and HCO3− transport with varying external pH. At the optimal carboxysome permeability, contributions from CO2 scavenging at the cell membrane are small. We examine the cumulative benefits of CCM spatial organization strategies: enzyme co-localization and compartmentalization.
Date issued
2014-04
URI
http://hdl.handle.net/1721.1/89423
Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Journal
eLife
Publisher
eLife Sciences Publications, Ltd.
Citation
Mangan, Niall M, and Michael P Brenner. “ Systems Analysis of the CO 2 Concentrating Mechanism in Cyanobacteria .” Abstract 3 (April 29, 2014).
Version: Final published version
ISSN
2050-084X

Collections
  • MIT Open Access Articles

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries
PrivacyPermissionsAccessibilityContact us
MIT
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.