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dc.contributor.authorDowen, Jill M.
dc.contributor.authorBilodeau, Steve
dc.contributor.authorOrlando, David A.
dc.contributor.authorHübner, Michael R.
dc.contributor.authorAbraham, Brian J.
dc.contributor.authorSpector, David L.
dc.contributor.authorYoung, Richard A.
dc.contributor.authorYoung, Richard A.
dc.date.accessioned2014-10-07T15:00:07Z
dc.date.available2014-10-07T15:00:07Z
dc.date.issued2013-11
dc.identifier.issn22136711
dc.identifier.urihttp://hdl.handle.net/1721.1/90570
dc.description.abstractTranscription factors control cell-specific gene expression programs by binding regulatory elements and recruiting cofactors and the transcription apparatus to the initiation sites of active genes. One of these cofactors is cohesin, a structural maintenance of chromosomes (SMC) complex that is necessary for proper gene expression. We report that a second SMC complex, condensin II, is also present at transcriptional regulatory elements of active genes during interphase and is necessary for normal gene activity. Both cohesin and condensin II are associated with genes in euchromatin and not heterochromatin. The two SMC complexes and the SMC loading factor NIPBL are particularly enriched at super-enhancers, and the genes associated with these regulatory elements are especially sensitive to reduced levels of these complexes. Thus, in addition to their well-established functions in chromosome maintenance during mitosis, both cohesin and condensin II make important contributions to the functions of the key transcriptional regulatory elements during interphase.en_US
dc.description.sponsorshipCanadian Institutes of Health Research (Fellowship)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (grant GM42694)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (grant HG002668)en_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (NIH, Ruth L. Kirschstein National Research Service Award (CA168263-01A1))en_US
dc.language.isoen_US
dc.publisherElsevier B.V.en_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.stemcr.2013.09.002en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en_US
dc.sourceElsevieren_US
dc.titleMultiple Structural Maintenance of Chromosome Complexes at Transcriptional Regulatory Elementsen_US
dc.typeArticleen_US
dc.identifier.citationDowen, Jill M., Steve Bilodeau, David A. Orlando, Michael R. Hübner, Brian J. Abraham, David L. Spector, and Richard A. Young. “Multiple Structural Maintenance of Chromosome Complexes at Transcriptional Regulatory Elements.” Stem Cell Reports 1, no. 5 (November 2013): 371–378.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorYoung, Richard A.en_US
dc.relation.journalStem Cell Reportsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsDowen, Jill M.; Bilodeau, Steve; Orlando, David A.; Hübner, Michael R.; Abraham, Brian J.; Spector, David L.; Young, Richard A.en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-8855-8647
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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