Cell-laden Microengineered and Mechanically Tunable Hybrid Hydrogels of Gelatin and Graphene Oxide
Author(s)Shin, Su Ryon; Aghaei-Ghareh-Bolagh, Behnaz; Dang, Tram T.; Topkaya, Seda Nur; Gao, Xiguang; Yang, Seung Yun; Jung, Sung Mi; Oh, Jong Hyun; Dokmeci, Mehmet; Tang, Xiaowu (Shirley); Khademhosseini, Ali; ... Show more Show less
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Incorporating graphene oxide inside GelMA hydrogels enhances their mechanical properties and reduces UV-induced cell damage while preserving their favorable characteristics for 3D cell encapsulation. NIH-3T3 fibroblasts encapsulated in GO-GelMA microgels demonstrate excellent cellular viability, proliferation, spreading, and alignment. GO reinforcement combined with a multi-stacking approach offers a facile engineering strategy for the construction of complex artificial tissues.
DepartmentHarvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
John Wiley & Sons, Inc
Shin, Su Ryon, Behnaz Aghaei-Ghareh-Bolagh, Tram T. Dang, Seda Nur Topkaya, Xiguang Gao, Seung Yun Yang, Sung Mi Jung, et al. “Cell-Laden Microengineered and Mechanically Tunable Hybrid Hydrogels of Gelatin and Graphene Oxide.” Advanced Materials 25, no. 44 (November 2013): 6385–6391.
Author's final manuscript