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dc.contributor.authorTan, Kelly R.
dc.contributor.authorTuriault, Marc
dc.contributor.authorMirzabekov, Julie J.
dc.contributor.authorDoehner, Jana
dc.contributor.authorDeisseroth, Karl
dc.contributor.authorTye, Kay
dc.contributor.authorYvon, Cedric
dc.contributor.authorLabouebe, Gwenael
dc.contributor.authorLuscher, Christian
dc.date.accessioned2014-11-13T19:31:36Z
dc.date.available2014-11-13T19:31:36Z
dc.date.issued2012-03
dc.date.submitted2012-02
dc.identifier.issn08966273
dc.identifier.issn1097-4199
dc.identifier.urihttp://hdl.handle.net/1721.1/91554
dc.description.abstractSalient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism underlying DA neuron inhibition has not been investigated and the causal link to behavior remains elusive. Here, we show that GABA neurons of the VTA inhibit DA neurons through neurotransmission at GABA[subscript A] receptors. We also observe that GABA neurons increase their firing in response to a footshock and provide evidence that driving GABA neurons with optogenetic effectors is sufficient to affect behavior. Taken together, our data demonstrate that synaptic inhibition of DA neurons drives place aversion.en_US
dc.description.sponsorshipSwiss National Science Foundationen_US
dc.description.sponsorshipNational Centres of Competence in Research (Switzerland)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). Ruth L. Kirschstein National Research Service Award (Fellowship F32 MH880102)en_US
dc.description.sponsorshipPicower Institute for Learning and Memoryen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.neuron.2012.02.015en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceElsevieren_US
dc.titleGABA Neurons of the VTA Drive Conditioned Place Aversionen_US
dc.typeArticleen_US
dc.identifier.citationTan, Kelly R., Cedric Yvon, Marc Turiault, Julie J. Mirzabekov, Jana Doehner, Gwenael Labouebe, Karl Deisseroth, Kay M. Tye, and Christian Luscher. “GABA Neurons of the VTA Drive Conditioned Place Aversion.” Neuron 73, no. 6 (March 2012): 1173–1183. © 2012 Elsevier Inc.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentPicower Institute for Learning and Memoryen_US
dc.contributor.mitauthorTye, Kayen_US
dc.relation.journalNeuronen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsTan, Kelly R.; Yvon, Cedric; Turiault, Marc; Mirzabekov, Julie J.; Doehner, Jana; Labouebe, Gwenael; Deisseroth, Karl; Tye, Kay M.; Luscher, Christianen_US
mit.licensePUBLISHER_POLICYen_US


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