dc.contributor.author | Tan, Kelly R. | |
dc.contributor.author | Turiault, Marc | |
dc.contributor.author | Mirzabekov, Julie J. | |
dc.contributor.author | Doehner, Jana | |
dc.contributor.author | Deisseroth, Karl | |
dc.contributor.author | Tye, Kay | |
dc.contributor.author | Yvon, Cedric | |
dc.contributor.author | Labouebe, Gwenael | |
dc.contributor.author | Luscher, Christian | |
dc.date.accessioned | 2014-11-13T19:31:36Z | |
dc.date.available | 2014-11-13T19:31:36Z | |
dc.date.issued | 2012-03 | |
dc.date.submitted | 2012-02 | |
dc.identifier.issn | 08966273 | |
dc.identifier.issn | 1097-4199 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/91554 | |
dc.description.abstract | Salient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism underlying DA neuron inhibition has not been investigated and the causal link to behavior remains elusive. Here, we show that GABA neurons of the VTA inhibit DA neurons through neurotransmission at GABA[subscript A] receptors. We also observe that GABA neurons increase their firing in response to a footshock and provide evidence that driving GABA neurons with optogenetic effectors is sufficient to affect behavior. Taken together, our data demonstrate that synaptic inhibition of DA neurons drives place aversion. | en_US |
dc.description.sponsorship | Swiss National Science Foundation | en_US |
dc.description.sponsorship | National Centres of Competence in Research (Switzerland) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.). Ruth L. Kirschstein National Research Service Award (Fellowship F32 MH880102) | en_US |
dc.description.sponsorship | Picower Institute for Learning and Memory | en_US |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1016/j.neuron.2012.02.015 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | Elsevier | en_US |
dc.title | GABA Neurons of the VTA Drive Conditioned Place Aversion | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Tan, Kelly R., Cedric Yvon, Marc Turiault, Julie J. Mirzabekov, Jana Doehner, Gwenael Labouebe, Karl Deisseroth, Kay M. Tye, and Christian Luscher. “GABA Neurons of the VTA Drive Conditioned Place Aversion.” Neuron 73, no. 6 (March 2012): 1173–1183. © 2012 Elsevier Inc. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
dc.contributor.department | Picower Institute for Learning and Memory | en_US |
dc.contributor.mitauthor | Tye, Kay | en_US |
dc.relation.journal | Neuron | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Tan, Kelly R.; Yvon, Cedric; Turiault, Marc; Mirzabekov, Julie J.; Doehner, Jana; Labouebe, Gwenael; Deisseroth, Karl; Tye, Kay M.; Luscher, Christian | en_US |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |