Microfluidic jet injection for delivering macromolecules into cells
Author(s)Roushdy, O.; Dokov, Rangel P.; Adamo, Andrea; Sharei, Armon Reza; Jensen, Klavs F.; Roushdy, O.; ... Show more Show less
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We present a microfluidic-based injection system designed to achieve intracellular delivery of macromolecules by directing a picoliter jet of a solution toward the individual cells. After discussing the concept, we present design specification and criteria, elucidate performance and discuss results. The method has the potential to be quantitative and of high throughput, overcoming the limitations of current intracellular delivery protocols.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Mechanical Engineering
Journal of Micromechanics and Microengineering
Adamo, A, O Roushdy, R Dokov, A Sharei, and K F Jensen. “Microfluidic Jet Injection for Delivering Macromolecules into Cells.” J. Micromech. Microeng. 23, no. 3 (February 6, 2013): 035026.
Author's final manuscript