Mass Production and Size Control of Lipid–Polymer Hybrid Nanoparticles through Controlled Microvortices
Author(s)Kim, YongTae; Lee Chung, Bomy; Ma, Mingming; Mulder, Willem J. M.; Fayad, Zahi A.; Farokhzad, Omid C.; Langer, Robert S; ... Show more Show less
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Lipid–polymer hybrid (LPH) nanoparticles can deliver a wide range of therapeutic compounds in a controlled manner. LPH nanoparticle syntheses using microfluidics improve the mixing process but are restricted by a low throughput. In this study, we present a pattern-tunable microvortex platform that allows mass production and size control of LPH nanoparticles with superior reproducibility and homogeneity. We demonstrate that by varying flow rates (i.e., Reynolds number (30–150)) we can control the nanoparticle size (30–170 nm) with high productivity (~3 g/hour) and low polydispersity (~0.1). Our approach may contribute to efficient development and optimization of a wide range of multicomponent nanoparticles for medical imaging and drug delivery.
DepartmentHarvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MIT
American Chemical Society (ACS)
Kim, YongTae, Bomy Lee Chung, Mingming Ma, Willem J. M. Mulder, Zahi A. Fayad, Omid C. Farokhzad, and Robert Langer. “Mass Production and Size Control of Lipid–Polymer Hybrid Nanoparticles through Controlled Microvortices.” Nano Lett. 12, no. 7 (July 11, 2012): 3587–3591.
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