Grounded: Transcriptional Pausing in Naive mESCs
Author(s)Guenther, Matthew G.; Young, Richard A.; Young, Richard A.
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Growing mouse pluripotent stem cells in defined media with signaling inhibitors establishes a naive ground state different from that of cells grown in serum. Recently in Cell, Marks et al. (2012) reported differences in the transcriptional and epigenomic landscapes of naive and serum-exposed mouse stem cells that improve our understanding of the pluripotent ground state.
DepartmentMassachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Cell Stem Cell
Guenther, Matthew G., and Richard A. Young. “Grounded: Transcriptional Pausing in Naive mESCs.” Cell Stem Cell 10, no. 5 (May 2012): 484–485. © 2012 Elsevier Inc.
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