| dc.contributor.author | Masuda, Hitomi | |
| dc.contributor.author | Nakamura, Kuniaki | |
| dc.contributor.author | Takata, Nozomu | |
| dc.contributor.author | Itoh, Bunsho | |
| dc.contributor.author | Hirose, Takashi | |
| dc.contributor.author | Moribe, Hiroki | |
| dc.contributor.author | Mekada, Eisuke | |
| dc.contributor.author | Okada, Masato | |
| dc.date.accessioned | 2014-11-20T13:19:40Z | |
| dc.date.available | 2014-11-20T13:19:40Z | |
| dc.date.issued | 2012-01 | |
| dc.date.submitted | 2012-01 | |
| dc.identifier.issn | 00145793 | |
| dc.identifier.issn | 1873-3468 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/91625 | |
| dc.description.abstract | The transmembrane protein MIG-13 is a key regulator required for anterior migration of neural cells in Caenorhabditis elegans, but the signaling mechanisms involved remain unknown. Here, we isolated a suppressor mutation in the unc-71/adm-1 gene, which rescued the AVM neuron migration defect in mig-13 mutants. Genetic analyses revealed that UNC-71 at least partly acts downstream of MIG-13 and has an inhibitory effect on the anterior cell migration. The unc-71 mutation also rescued the anterior migration defect of AVM neuron in src-1 mutants. These findings suggest that MIG-13 controls anteroposterior cell migration by interacting with UNC-71 and SRC-1 in C. elegans. | en_US |
| dc.description.sponsorship | Uehara Memorial Foundation | en_US |
| dc.description.sponsorship | Japan. Ministry of Education, Culture, Sports, Science and Technology (Grant-in-Aid for Scientific Research) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Elsevier | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1016/j.febslet.2012.01.031 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | Elsevier | en_US |
| dc.title | MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Masuda, Hitomi, Kuniaki Nakamura, Nozomu Takata, Bunsho Itoh, Takashi Hirose, Hiroki Moribe, Eisuke Mekada, and Masato Okada. “MIG-13 Controls Anteroposterior Cell Migration by Interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis Elegans.” FEBS Letters 586, no. 6 (March 2012): 740–746. © 2012 Federation of European Biochemical Societies | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.mitauthor | Hirose, Takashi | en_US |
| dc.relation.journal | FEBS Letters | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Masuda, Hitomi; Nakamura, Kuniaki; Takata, Nozomu; Itoh, Bunsho; Hirose, Takashi; Moribe, Hiroki; Mekada, Eisuke; Okada, Masato | en_US |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
