| dc.contributor.author | Van Lehn, Reid C. | |
| dc.contributor.author | Atukorale, Prabhani U. | |
| dc.contributor.author | Carney, Randy P. | |
| dc.contributor.author | Yang, Yu-Sang Sabrina | |
| dc.contributor.author | Stellacci, Francesco | |
| dc.contributor.author | Irvine, Darrell J. | |
| dc.contributor.author | Alexander-Katz, Alfredo | |
| dc.date.accessioned | 2014-11-20T14:24:52Z | |
| dc.date.available | 2014-11-20T14:24:52Z | |
| dc.date.issued | 2013-08 | |
| dc.date.submitted | 2013-07 | |
| dc.identifier.issn | 1530-6984 | |
| dc.identifier.issn | 1530-6992 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/91636 | |
| dc.description.abstract | Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the penetration process is potentially the fusion of such AuNPs with lipid bilayers. Free energy calculations, experiments on unilamellar and multilamellar vesicles, and cell studies all support this hypothesis. Furthermore, we show that fusion is only favorable for AuNPs with core diameters below a critical size that depends on the monolayer composition. | en_US |
| dc.description.sponsorship | National Science Foundation (U.S.). Graduate Research Fellowship Program | en_US |
| dc.description.sponsorship | National Science Foundation (U.S.). Materials Research Science and Engineering Centers (Program) (Award DMR-0819762) | en_US |
| dc.description.sponsorship | National Cancer Institute (U.S.) (Award U54CA143874) | en_US |
| dc.description.sponsorship | United States. Army Research Office (Contract W911NF-13-D-0001) | en_US |
| dc.description.sponsorship | United States. Army Research Office (Contract W911NF-07-D-0004, T.O. 8) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/nl401365n | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | Effect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Van Lehn, Reid C., Prabhani U. Atukorale, Randy P. Carney, Yu-Sang Yang, Francesco Stellacci, Darrell J. Irvine, and Alfredo Alexander-Katz. “Effect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers.” Nano Lett. 13, no. 9 (September 11, 2013): 4060–4067. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Materials Science and Engineering | en_US |
| dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
| dc.contributor.mitauthor | Van Lehn, Reid C. | en_US |
| dc.contributor.mitauthor | Yang, Yu-Sang Sabrina | en_US |
| dc.contributor.mitauthor | Irvine, Darrell J. | en_US |
| dc.contributor.mitauthor | Alexander-Katz, Alfredo | en_US |
| dc.contributor.mitauthor | Atukorale, Prabhani U. | en_US |
| dc.relation.journal | Nano Letters | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Van Lehn, Reid C.; Atukorale, Prabhani U.; Carney, Randy P.; Yang, Yu-Sang; Stellacci, Francesco; Irvine, Darrell J.; Alexander-Katz, Alfredo | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0001-5554-1283 | |
| dspace.mitauthor.error | true | |
| mit.license | OPEN_ACCESS_POLICY | en_US |
| mit.metadata.status | Complete | |
