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dc.contributor.authorLander, Eric S.
dc.contributor.authorHodis, Eran
dc.date.accessioned2014-11-20T14:30:31Z
dc.date.available2014-11-20T14:30:31Z
dc.date.issued2012-09
dc.date.submitted2012-07
dc.identifier.issn00928674
dc.identifier.issn1097-4172
dc.identifier.urihttp://hdl.handle.net/1721.1/91638
dc.description.abstractLung adenocarcinoma, the most common subtype of non-small cell lung cancer, is responsible for more than 500,000 deaths per year worldwide. Here, we report exome and genome sequences of 183 lung adenocarcinoma tumor/normal DNA pairs. These analyses revealed a mean exonic somatic mutation rate of 12.0 events/megabase and identified the majority of genes previously reported as significantly mutated in lung adenocarcinoma. In addition, we identified statistically recurrent somatic mutations in the splicing factor gene U2AF1 and truncating mutations affecting RBM10 and ARID1A. Analysis of nucleotide context-specific mutation signatures grouped the sample set into distinct clusters that correlated with smoking history and alterations of reported lung adenocarcinoma genes. Whole-genome sequence analysis revealed frequent structural rearrangements, including in-frame exonic alterations within EGFR and SIK2 kinases. The candidate genes identified in this study are attractive targets for biological characterization and therapeutic targeting of lung adenocarcinoma.en_US
dc.description.sponsorshipNational Institute of General Medical Sciences (U.S.) (Training Grant T32GM07753)en_US
dc.description.sponsorshipNational Human Genome Research Institute (U.S.)en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.cell.2012.08.029en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceElsevieren_US
dc.titleMapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencingen_US
dc.typeArticleen_US
dc.identifier.citationImielinski, Marcin, Alice H. Berger, Peter S. Hammerman, Bryan Hernandez, Trevor J. Pugh, Eran Hodis, Jeonghee Cho, et al. “Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing.” Cell 150, no. 6 (September 2012): 1107–1120. © 2012 Elsevier Inc.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorLander, Eric S.en_US
dc.contributor.mitauthorHodis, Eranen_US
dc.relation.journalCellen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsImielinski, Marcin; Berger, Alice H.; Hammerman, Peter S.; Hernandez, Bryan; Pugh, Trevor J.; Hodis, Eran; Cho, Jeonghee; Suh, James; Capelletti, Marzia; Sivachenko, Andrey; Sougnez, Carrie; Auclair, Daniel; Lawrence, Michael S.; Stojanov, Petar; Cibulskis, Kristian; Choi, Kyusam; de Waal, Luc; Sharifnia, Tanaz; Brooks, Angela; Greulich, Heidi; Banerji, Shantanu; Zander, Thomas; Seidel, Danila; Leenders, Frauke; Ansen, Sascha; Ludwig, Corinna; Engel-Riedel, Walburga; Stoelben, Erich; Wolf, Jurgen; Goparju, Chandra; Thompson, Kristin; Winckler, Wendy; Kwiatkowski, David; Johnson, Bruce E.; Janne, Pasi A.; Miller, Vincent A.; Pao, William; Travis, William D.; Pass, Harvey I.; Gabriel, Stacey B.; Lander, Eric S.; Thomas, Roman K.; Garraway, Levi A.; Getz, Gad; Meyerson, Matthewen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-1744-2126
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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