mTOR Signaling in Growth Control and Disease

Author(s)
Laplante, Mathieu; Sabatini, David M.; Sabatini, David
Thumbnail
DownloadLaplante-2012-mTOR Signaling in Gr.pdf (1.850Mb)
PUBLISHER_POLICY
Terms of use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Metadata
Show full item record
Abstract
The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration. Here, we review recent advances in our understanding of the mTOR pathway and its role in health, disease, and aging. We further discuss pharmacological approaches to treat human pathologies linked to mTOR deregulation.
Date issued
2012-04
URI
http://hdl.handle.net/1721.1/91891
Department
Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research; Koch Institute for Integrative Cancer Research at MIT
Journal
Cell
Publisher
Elsevier
Citation
Laplante, Mathieu, and David M. Sabatini. “mTOR Signaling in Growth Control and Disease.” Cell 149, no. 2 (April 2012): 274–293. © 2012 Elsevier Inc.
Version: Final published version
ISSN
00928674
1097-4172
Collections