Engineering Nano- and Microparticles to Tune Immunity
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Irvine_Engineering nano.pdf
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5 MB
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Author(s)
Moon, James J.
Huang, Bonnie
Irvine, Darrell J
Date Issued
May 2012
Journal
Advanced Materials
Publisher
Wiley Blackwell
Citation
Moon, James J., Bonnie Huang, and Darrell J. Irvine. “Engineering Nano- and Microparticles to Tune Immunity.” Advanced Materials 24, no. 28 (May 29, 2012): 3724–3746.
Version
Author's final manuscript
Abstract
The immune system can be a cure or cause of disease, fulfilling a protective role in attacking cancer or pathogenic microbes but also causing tissue destruction in autoimmune disorders. Thus, therapies aimed to amplify or suppress immune reactions are of great interest. However, the complex regulation of the immune system, coupled with the potential systemic side effects associated with traditional systemic drug therapies, has presented a major hurdle for the development of successful immunotherapies. Recent progress in the design of synthetic micro- and nano-particles that can target drugs, deliver imaging agents, or stimulate immune cells directly through their physical and chemical properties is leading to new approaches to deliver vaccines, promote immune responses against tumors, and suppress autoimmunity. In addition, novel strategies, such as the use of particle-laden immune cells as living targeting agents for drugs, are providing exciting new approaches for immunotherapy. This progress report describes recent advances in the design of micro- and nano-particles for immunotherapies and diagnostics.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Ragon Institute of MGH, MIT and Harvard
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/adma.201200446
