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dc.contributor.authorLiu, Vincent Hok
dc.contributor.authorVassiliou, Vassiliou, Christophoros C.
dc.contributor.authorImaad, Syed M.
dc.contributor.authorCima, Michael J.
dc.contributor.authorVassiliou, Christophoros C.
dc.date.accessioned2014-12-01T15:55:36Z
dc.date.available2014-12-01T15:55:36Z
dc.date.issued2014-04
dc.date.submitted2014-01
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/1721.1/91953
dc.description.abstractTargeted MRI contrast agents have proven useful in research and clinical studies for highlighting specific metabolites and biomarkers [Davies GL, et al. (2013) Chem Commun (Camb) 49(84):9704–9721] but their applicability in serial imaging is limited owing to a changing concentration postinjection. Solid enclosures have previously been used to keep the local concentration of contrast agent constant, but the need to surgically implant these devices limits their use [Daniel K, et al. (2009) Biosens Bioelectron 24(11):3252–3257]. This paper describes a novel class of contrast agent that comprises a responsive material for contrast generation and an injectable polymeric matrix for structural support. Using this principle, we have designed a contrast agent sensitive to oxygen, which is composed of dodecamethylpentasiloxane as the responsive material and polydimethylsiloxane as the matrix material. A rodent inspired-gas model demonstrated that these materials are functionally stable in vivo for at least 1 mo, which represents an order of magnitude improvement over an injection of liquid siloxane [Kodibagkar VD, et al. (2006) Magn Reson Med 55(4):743–748]. We also observed minimal adverse tissue reactions or migration of contrast agents from the initial injection site. This class of contrast agents, thus, represented a new and complementary method to monitor chronic diseases by MRI.en_US
dc.description.sponsorshipUnited States. Army Research Office (Grant W911NF-13-D-0001)en_US
dc.description.sponsorshipMIT-Harvard Center for Cancer Nanotechnology Excellence (Grant 5U54CA151884-03)en_US
dc.language.isoen_US
dc.publisherNational Academy of Sciences (U.S.)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1073/pnas.1400015111en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceNational Academy of Sciences (U.S.)en_US
dc.titleSolid MRI contrast agents for long-term, quantitative in vivo oxygen sensingen_US
dc.typeArticleen_US
dc.identifier.citationLiu, V. H., C. C. Vassiliou, S. M. Imaad, and M. J. Cima. “Solid MRI Contrast Agents for Long-Term, Quantitative in Vivo Oxygen Sensing.” Proceedings of the National Academy of Sciences 111, no. 18 (April 21, 2014): 6588–6593. © National Academy of Sciencesen_US
dc.contributor.departmentDavid H. Koch Institute for Integrative Cancer Research at MITen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Materials Science and Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Lemelson-MIT Awards Programen_US
dc.contributor.mitauthorLiu, Vincent Hoken_US
dc.contributor.mitauthorVassiliou, Christophoros C.en_US
dc.contributor.mitauthorImaad, Syed M.en_US
dc.contributor.mitauthorCima, Michael J.en_US
dc.relation.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsLiu, Vincent H.; Vassiliou, Christophoros C.; Imaad, Syed M.; Cima, Michael J.en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-0834-5823
dc.identifier.orcidhttps://orcid.org/0000-0003-2379-6139
mit.licensePUBLISHER_POLICYen_US


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