MIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls

Author(s)
Barker, Nick; van Oudenaarden, Alexander; Clevers, Hans; van Oudenaarden, Alexander
Thumbnail
DownloadBarker-2012-Identifying the Stem.pdf (1.006Mb)
PUBLISHER_POLICY

Publisher Policy

Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.

Terms of use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Metadata
Show full item record
Abstract
Decades ago, two nonoverlapping crypt stem cell populations were proposed: Leblond’s Crypt Base Columnar (CBC) cell and Potten’s +4 cell. The identification of CBC markers including Lgr5 has confirmed Leblond’s predictions that CBC cells are anatomically distinct, long-lived stem cells that permanently cycle. While Potten originally described +4 cells as proliferative and unusually radiation-sensitive, recent efforts to identify +4 stem cells have focused on the identification of cells that are quiescent and radiation-resistant. Here, we describe commonalities and discrepancies between the individual studies and discuss challenges of marker-based lineage tracing.
Date issued
2012-10
URI
http://hdl.handle.net/1721.1/91960
Department
Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Physics
Journal
Cell Stem Cell
Publisher
Elsevier
Citation
Barker, Nick, Alexander van Oudenaarden, and Hans Clevers. “Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls.” Cell Stem Cell 11, no. 4 (October 2012): 452–460. © 2012 Elsevier Inc.
Version: Final published version
ISSN
19345909

Collections
  • MIT Open Access Articles

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries
PrivacyPermissionsAccessibilityContact us
MIT
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.