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dc.contributor.authorPan, Keyao
dc.contributor.authorKim, Do-Nyun
dc.contributor.authorZhang, Fei
dc.contributor.authorYan, Hao
dc.contributor.authorBathe, Mark
dc.contributor.authorAdendorff, Matthew Ralph
dc.date.accessioned2014-12-03T17:00:55Z
dc.date.available2014-12-03T17:00:55Z
dc.date.issued2014-12
dc.date.submitted2014-07
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/1721.1/92017
dc.description.abstractDNA can be programmed to self-assemble into high molecular weight 3D assemblies with precise nanometer-scale structural features. Although numerous sequence design strategies exist to realize these assemblies in solution, there is currently no computational framework to predict their 3D structures on the basis of programmed underlying multi-way junction topologies constrained by DNA duplexes. Here, we introduce such an approach and apply it to assemblies designed using the canonical immobile four-way junction. The procedure is used to predict the 3D structure of high molecular weight planar and spherical ring-like origami objects, a tile-based sheet-like ribbon, and a 3D crystalline tensegrity motif, in quantitative agreement with experiments. Our framework provides a new approach to predict programmed nucleic acid 3D structure on the basis of prescribed secondary structure motifs, with possible application to the design of such assemblies for use in biomolecular and materials science.en_US
dc.description.sponsorshipUnited States. Office of Naval Research (ONR N000141210621)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (NSF-DMREF Program CMMI1334109)en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/ncomms6578en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceNatureen_US
dc.titleLattice-free prediction of three-dimensional structure of programmed DNA assembliesen_US
dc.typeArticleen_US
dc.identifier.citationPan, Keyao et al. “Lattice-Free Prediction of Three-Dimensional Structure of Programmed DNA Assemblies.” Nature Communications 5 (2014): 5578.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.mitauthorPan, Keyaoen_US
dc.contributor.mitauthorAdendorff, Matthew Ralphen_US
dc.contributor.mitauthorBathe, Marken_US
dc.relation.journalNature Communicationsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsPan, Keyao; Kim, Do-Nyun; Zhang, Fei; Adendorff, Matthew R.; Yan, Hao; Bathe, Marken_US
dc.identifier.orcidhttps://orcid.org/0000-0002-9538-4996
dc.identifier.orcidhttps://orcid.org/0000-0003-4573-5206
dc.identifier.orcidhttps://orcid.org/0000-0002-6199-6855
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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