The Cellular Basis for Animal Regeneration
Author(s)Tanaka, Elly M.; Reddien, Peter
MetadataShow full item record
The ability of animals to regenerate missing parts is a dramatic and poorly understood aspect of biology. The sources of new cells for these regenerative phenomena have been sought for decades. Recent advances involving cell fate tracking in complex tissues have shed new light on the cellular underpinnings of regeneration in Hydra, planarians, zebrafish, Xenopus, and Axolotl. Planarians accomplish regeneration with use of adult pluripotent stem cells, whereas several vertebrates utilize a collection of lineage-restricted progenitors from different tissues. Together, an array of cellular strategies—from pluripotent stem cells to tissue-specific stem cells and dedifferentiation—are utilized for regeneration.
DepartmentMassachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Tanaka, Elly M., and Peter W. Reddien. “The Cellular Basis for Animal Regeneration.” Developmental Cell 21, no. 1 (July 2011): 172–185. © 2011 Elsevier Inc.
Final published version