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dc.contributor.authorWeinberg, Robert A.
dc.contributor.authorValastyan, Scott John
dc.contributor.authorWeinberg, Robert A
dc.date.accessioned2014-12-08T17:57:47Z
dc.date.available2014-12-08T17:57:47Z
dc.date.issued2011-10
dc.identifier.issn00928674
dc.identifier.issn1097-4172
dc.identifier.urihttp://hdl.handle.net/1721.1/92053
dc.description.abstractMetastases represent the end products of a multistep cell-biological process termed the invasion-metastasis cascade, which involves dissemination of cancer cells to anatomically distant organ sites and their subsequent adaptation to foreign tissue microenvironments. Each of these events is driven by the acquisition of genetic and/or epigenetic alterations within tumor cells and the co-option of nonneoplastic stromal cells, which together endow incipient metastatic cells with traits needed to generate macroscopic metastases. Recent advances provide provocative insights into these cell-biological and molecular changes, which have implications regarding the steps of the invasion-metastasis cascade that appear amenable to therapeutic targeting.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.)en_US
dc.description.sponsorshipUnited States. Dept. of Defenseen_US
dc.description.sponsorshipBreast Cancer Research Foundationen_US
dc.description.sponsorshipDamon Runyon Cancer Research Foundation (Fellowship)en_US
dc.description.sponsorshipMassachusetts Institute of Technology. Ludwig Center for Molecular Oncologyen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.cell.2011.09.024en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceElsevieren_US
dc.titleTumor Metastasis: Molecular Insights and Evolving Paradigmsen_US
dc.typeArticleen_US
dc.identifier.citationValastyan, Scott, and Robert A. Weinberg. “Tumor Metastasis: Molecular Insights and Evolving Paradigms.” Cell 147, no. 2 (October 2011): 275–292. © 2011 Elsevier Inc.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.departmentLudwig Center for Molecular Oncology (Massachusetts Institute of Technology)en_US
dc.contributor.mitauthorWeinberg, Robert A.en_US
dc.contributor.mitauthorValastyan, Scotten_US
dc.relation.journalCellen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsValastyan, Scott; Weinberg, Robert A.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-0895-3557
mit.licensePUBLISHER_POLICYen_US


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