dc.contributor.author | Nakano, Shunji | |
dc.contributor.author | Stillman, Bruce | |
dc.contributor.author | Horvitz, Howard Robert | |
dc.date.accessioned | 2014-12-16T19:32:25Z | |
dc.date.available | 2014-12-16T19:32:25Z | |
dc.date.issued | 2011-12 | |
dc.date.submitted | 2011-09 | |
dc.identifier.issn | 00928674 | |
dc.identifier.issn | 1097-4172 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/92340 | |
dc.description.abstract | Although replication-coupled chromatin assembly is known to be important for the maintenance of patterns of gene expression through sequential cell divisions, the role of replication-coupled chromatin assembly in controlling cell differentiation during animal development remains largely unexplored. Here we report that the CAF-1 protein complex, an evolutionarily conserved histone chaperone that deposits histone H3-H4 proteins onto replicating DNA, is required to generate a bilateral asymmetry in the C. elegans nervous system. A mutation in 1 of 24 C. elegans histone H3 genes specifically eliminates this aspect of neuronal asymmetry by causing a defect in the formation of a histone H3-H4 tetramer and the consequent inhibition of CAF-1-mediated nucleosome formation. Our results reveal that replication-coupled nucleosome assembly is necessary to generate a bilateral asymmetry in C. elegans neuroanatomy and suggest that left-right asymmetric epigenetic regulation can establish bilateral asymmetry in the nervous system. | en_US |
dc.description.sponsorship | Howard Hughes Medical Institute | en_US |
dc.description.sponsorship | National Cancer Institute (U.S.) (Grant CA13106) | en_US |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1016/j.cell.2011.11.053 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | Elsevier | en_US |
dc.title | Replication-Coupled Chromatin Assembly Generates a Neuronal Bilateral Asymmetry in C. elegans | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Nakano, Shunji, Bruce Stillman, and H. Robert Horvitz. “Replication-Coupled Chromatin Assembly Generates a Neuronal Bilateral Asymmetry in C. Elegans.” Cell 147, no. 7 (December 2011): 1525–1536. © 2011 Elsevier Inc. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
dc.contributor.mitauthor | Horvitz, H. Robert | en_US |
dc.contributor.mitauthor | Nakano, Shunji | en_US |
dc.relation.journal | Cell | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Nakano, Shunji; Stillman, Bruce; Horvitz, H. Robert | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-9964-9613 | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |