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dc.contributor.authorO’Brien, Caroline C.
dc.contributor.authorKolachalama, Vijaya Bhasker
dc.contributor.authorBarber, Tracie J.
dc.contributor.authorSimmons, Anne
dc.contributor.authorEdelman, Elazer R.
dc.date.accessioned2014-12-18T17:54:04Z
dc.date.available2014-12-18T17:54:04Z
dc.date.issued2013-06
dc.identifier.issn01683659
dc.identifier.urihttp://hdl.handle.net/1721.1/92381
dc.description.abstractDrug-eluting stents reside in a dynamic fluid environment where the extent to which drugs are distributed within the arterial wall is critically modulated by the blood flowing through the arterial lumen. Yet several factors associated with the pulsatile nature of blood flow and their impact on arterial drug deposition have not been fully investigated. We employed an integrated framework comprising bench-top and computational models to explore the factors governing the time-varying fluid dynamic environment within the vasculature and their effects on arterial drug distribution patterns. A custom-designed bench-top framework comprising a model of a single drug-eluting stent strut and a poly-vinyl alcohol-based hydrogel as a model tissue bed simulated fluid flow and drug transport under fully apposed strut settings. Bench-top experiments revealed a relative independence between drug distribution and the factors governing pulsatile flow and these findings were validated with the in silico model. Interestingly, computational models simulating suboptimal deployment settings revealed a complex interplay between arterial drug distribution, Womersley number and the extent of malapposition. In particular, for a stent strut offset from the wall, total drug deposition was sensitive to changes in the pulsatile flow environment, with this dependence increasing with greater wall displacement. Our results indicate that factors governing pulsatile luminal flow on arterial drug deposition should be carefully considered in conjunction with device deployment settings for better utilization of drug-eluting stent therapy.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (grant NIH R01 GM-49039)en_US
dc.language.isoen_US
dc.publisherElsevier B.V.en_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.jconrel.2013.03.014en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleImpact of flow pulsatility on arterial drug distribution in stent-based therapyen_US
dc.typeArticleen_US
dc.identifier.citationO’Brien, Caroline C., Vijaya B. Kolachalama, Tracie J. Barber, Anne Simmons, and Elazer R. Edelman. “Impact of Flow Pulsatility on Arterial Drug Distribution in Stent-Based Therapy.” Journal of Controlled Release 168, no. 2 (June 2013): 115–124.en_US
dc.contributor.departmentInstitute for Medical Engineering and Scienceen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.mitauthorO’Brien, Caroline C.en_US
dc.contributor.mitauthorKolachalama, Vijaya Bhaskeren_US
dc.contributor.mitauthorEdelman, Elazer R.en_US
dc.relation.journalJournal of Controlled Releaseen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsO'Brien, Caroline C.; Kolachalama, Vijaya B.; Barber, Tracie J.; Simmons, Anne; Edelman, Elazer R.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7832-7156
dc.identifier.orcidhttps://orcid.org/0000-0002-2890-2319
dspace.mitauthor.errortrue
mit.licenseOPEN_ACCESS_POLICYen_US


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