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dc.contributor.authorLuchicchi, Antonio
dc.contributor.authorBloem, Bernard
dc.contributor.authorViaña, John Noel M.
dc.contributor.authorMansvelder, Huibert D.
dc.contributor.authorRole, Lorna W.
dc.date.accessioned2014-12-24T18:31:42Z
dc.date.available2014-12-24T18:31:42Z
dc.date.issued2014-10
dc.date.submitted2014-08
dc.identifier.issn1663-3563
dc.identifier.urihttp://hdl.handle.net/1721.1/92511
dc.description.abstractAcetylcholine (ACh) signaling underlies specific aspects of cognitive functions and behaviors, including attention, learning, memory and motivation. Alterations in ACh signaling are involved in the pathophysiology of multiple neuropsychiatric disorders. In the central nervous system, ACh transmission is mainly guaranteed by dense innervation of select cortical and subcortical regions from disperse groups of cholinergic neurons within the basal forebrain (BF; e.g., diagonal band, medial septal, nucleus basalis) and the pontine-mesencephalic nuclei, respectively. Despite the fundamental role of cholinergic signaling in the CNS and the long standing knowledge of the organization of cholinergic circuitry, remarkably little is known about precisely how ACh release modulates cortical and subcortical neural activity and the behaviors these circuits subserve. Growing interest in cholinergic signaling in the CNS focuses on the mechanism(s) of action by which endogenously released ACh regulates cognitive functions, acting as a neuromodulator and/or as a direct transmitter via nicotinic and muscarinic receptors. The development of optogenetic techniques has provided a valuable toolbox with which we can address these questions, as it allows the selective manipulation of the excitability of cholinergic inputs to the diverse array of cholinergic target fields within cortical and subcortical domains. Here, we review recent papers that use the light-sensitive opsins in the cholinergic system to elucidate the role of ACh in circuits related to attention and emotionally salient behaviors. In particular, we highlight recent optogenetic studies which have tried to disentangle the precise role of ACh in the modulation of cortical-, hippocampal- and striatal-dependent functions.en_US
dc.language.isoen_US
dc.publisherFrontiers Research Foundationen_US
dc.relation.isversionofhttp://dx.doi.org/10.3389/fnsyn.2014.00024en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceFrontiers Research Foundationen_US
dc.titleIlluminating the role of cholinergic signaling in circuits of attention and emotionally salient behaviorsen_US
dc.typeArticleen_US
dc.identifier.citationLuchicchi, Antonio, Bernard Bloem, John Noel M. Viaña, Huibert D. Mansvelder, and Lorna W. Role. “Illuminating the Role of Cholinergic Signaling in Circuits of Attention and Emotionally Salient Behaviors.” Frontiers in Synaptic Neuroscience 6 (October 27, 2014).en_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.mitauthorBloem, Bernarden_US
dc.relation.journalFrontiers in Synaptic Neuroscienceen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsLuchicchi, Antonio; Bloem, Bernard; Viaña, John Noel M.; Mansvelder, Huibert D.; Role, Lorna W.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-0930-580X
mit.licensePUBLISHER_CCen_US


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