Zebrafish as a model to study live mucus physiology
Author(s)Jevtov, Irena; Samuelsson, Tore; Yao, Grace; Amsterdam, Adam; Ribbeck, Katharina
MetadataShow full item record
Dysfunctional mucus barriers can result in important pulmonary and gastrointestinal conditions, but model systems to study the underlying causes are largely missing. We identified and characterized five mucin homologues in zebrafish, and demonstrated a strategy for fluorescence labeling of one selected mucin. These tools can be used for in vivo experiments and in pharmacological and genetic screens to study the dynamics and mechanisms of mucosal physiology.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biological Engineering
Nature Publishing Group
Jevtov, Irena, Tore Samuelsson, Grace Yao, Adam Amsterdam, and Katharina Ribbeck. “Zebrafish as a Model to Study Live Mucus Physiology.” Sci. Rep. 4 (October 17, 2014): 6653.
Final published version