Zebrafish as a model to study live mucus physiology

Author(s)
Jevtov, Irena; Samuelsson, Tore; Yao, Grace; Amsterdam, Adam; Ribbeck, Katharina
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Abstract
Dysfunctional mucus barriers can result in important pulmonary and gastrointestinal conditions, but model systems to study the underlying causes are largely missing. We identified and characterized five mucin homologues in zebrafish, and demonstrated a strategy for fluorescence labeling of one selected mucin. These tools can be used for in vivo experiments and in pharmacological and genetic screens to study the dynamics and mechanisms of mucosal physiology.
Date issued
2014-10
URI
http://hdl.handle.net/1721.1/92571
Department
Massachusetts Institute of Technology. Department of Biological Engineering; Koch Institute for Integrative Cancer Research at MIT
Journal
Scientific Reports
Publisher
Nature Publishing Group
Citation
Jevtov, Irena, Tore Samuelsson, Grace Yao, Adam Amsterdam, and Katharina Ribbeck. “Zebrafish as a Model to Study Live Mucus Physiology.” Sci. Rep. 4 (October 17, 2014): 6653.
Version: Final published version
ISSN
2045-2322
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